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calsequestrin 2

Summary

Gene Symbol

CASQ2

Organism

Homo sapiens (human)

External Links

NCBI Gene

845

KEGG Gene ID

PubChem

845

Alliance of Genome Resources

HGNC:1513

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Disease variant
Glycoprotein
Metal-binding
Muscle protein
Phosphoprotein
Proteomics identification
Reference proteome
Sarcoplasmic reticulum
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O14958	Calsequestrin, cardiac muscle isoform

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
regulation of heart rate	IMP
regulation of heart rate	IEA
detection of calcium ion	TAS
intracellular calcium ion homeostasis	IMP
striated muscle contraction	TAS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

Purkinje myocyte to ventricular cardiac muscle cell signaling

cell communication involved in cardiac conduction [inference]

Purkinje myocyte to ventricular cardiac muscle cell communication [inference]

Purkinje myocyte to ventricular cardiac muscle cell signaling

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction

cardiac muscle contraction

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to metal ion [inference]

response to calcium ion [inference]

detection of calcium ion

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

Purkinje myocyte to ventricular cardiac muscle cell signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

negative regulation of potassium ion transport

regulation of calcium ion transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

negative regulation of monoatomic ion transport [inference]

negative regulation of potassium ion transport

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of potassium ion transport

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of potassium ion transport

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cell communication [inference]

regulation of cell communication by electrical coupling

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of membrane repolarization

regulation of membrane repolarization during action potential [inference]

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of action potential [inference]

regulation of membrane repolarization during action potential [inference]

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of biological quality [inference]

regulation of heart rate

regulation of membrane potential [inference]

regulation of membrane repolarization

regulation of membrane repolarization during action potential [inference]

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

regulation of action potential [inference]

regulation of membrane repolarization during action potential [inference]

regulation of membrane repolarization during cardiac muscle cell action potential [inference]

regulation of membrane repolarization during ventricular cardiac muscle cell action potential

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA
junctional sarcoplasmic reticulum membrane	TAS
sarcoplasmic reticulum	ISS
Z disc	ISS
Z disc	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

junctional membrane complex

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

junctional sarcoplasmic reticulum membrane

bounding membrane of organelle [inference]

sarcoplasmic reticulum membrane

junctional sarcoplasmic reticulum membrane

Z disc

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen [inference]

sarcoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IDA
calcium ion binding	IBA
calcium ion binding	IEA
protein binding	IPI
protein homodimerization activity

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

calcium-dependent protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular sequestering activity [inference]

metal ion sequestering activity [inference]

calcium ion sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Calsequestrin

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 2** entries
InterPro
Calsequestrin
Thioredoxin-like superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060676	catecholaminergic polymorphic ventricular tachycardia 2	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	12373	MGI:1309469
Rattus norvegicus	29209	RGD:2276
Caenorhabditis elegans	181563	WB:WBGene00000822

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements