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Standards Ontologies Notations
Guidelines
MIRAGE
calcium sensing receptor

Summary
Gene Symbol
  • CASR
Organism
Homo sapiens (human)
NCBI Gene
846
KEGG Gene ID
PubChem
846
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • Cell membrane
  • Disease variant
  • Disulfide bond
  • Epilepsy
  • G-protein coupled receptor
  • Glycoprotein
  • Metal-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Signal
  • Transmembrane helix
  • Ubl conjugation
Proteins
Displaying 1 entry
UniProt Protein Name
P41180
  • Parathyroid cell calcium-sensing receptor 1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 49 in total
GO Term Evidence Code PMID
ossification
ossification
response to ischemia
detection of calcium ion
detection of calcium ion
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
metabotropic glutamate receptor
Functional Category
  • E: Amino acid transport and metabolism
  • M: Cell wall/membrane/envelope biogenesis
  • T: Signal transduction mechanisms
Displaying all 7 entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, extracellular calcium-sensing receptor-related
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region
Disease
Disease Ontology
Displaying all 10 entries
DO ID Disease Name Source
DOID:0080652 calcium oxalate nephrolithiasis
DOID:13543 hyperparathyroidism
DOID:585 nephrolithiasis
DOID:12678 hypercalcemia
DOID:1059 intellectual disability
DOID:0111322 obsolete idiopathic generalized epilepsy 8
DOID:0060700 familial hypocalciuric hypercalcemia 1
DOID:0090109 autosomal dominant hypocalcemia
DOID:0090107 autosomal dominant hypocalcemia 1
DOID:12466 secondary hyperparathyroidism
Ortholog
Displaying all 2 entries
Species Gene ID Alliance of Genome Resources
12374 MGI:1351351
24247 RGD:2277
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026