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Guidelines

MIRAGE

3-isopropylmalate dehydrogenase

Summary

Gene Symbol

LEU2

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

850342

PubChem

850342

Alliance of Genome Resources

SGD:S000000523

Annotation

Keyword

Cytoplasm
Leucine biosynthesis
Magnesium
Manganese
Metal-binding
NAD
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P04173	Beta-IPM dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glyoxylate cycle	IMP	23642236
leucine biosynthetic process	IMP	6297759

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

glyoxylate cycle

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

glyoxylate cycle

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine biosynthetic process

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

leucine biosynthetic process

branched-chain amino acid biosynthetic process [inference]

leucine biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA
cytosol	IDA	4355481
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
magnesium ion binding	IEA
3-isopropylmalate dehydrogenase activity	IDA	3071718
3-isopropylmalate dehydrogenase activity	IMP	6297759
3-isopropylmalate dehydrogenase activity	IBA
3-isopropylmalate dehydrogenase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-isopropylmalate dehydrogenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

isopropylmalate dehydrogenase 3

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
3-isopropylmalate dehydrogenase activity
amino acid biosynthetic process
branched-chain amino acid biosynthetic process
leucine biosynthetic process
magnesium ion binding
metal ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 3** entries
InterPro
Isocitrate/isopropylmalate dehydrogenase, conserved site
Isopropylmalate dehydrogenase-like domain
Isopropylmalate dehydrogenase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cytosol	PMID:4355481

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Last updated: April 7, 2025