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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

Srb8p

Summary

Gene Symbol

SRB8

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

850442

KEGG Gene ID

PubChem

850442

Alliance of Genome Resources

SGD:S000000677

Annotation

Keyword

3D-structure
Activator
Nucleus
Reference proteome
Repressor
Transcription regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
P25648	Mediator complex subunit 12 Suppressor of RNA polymerase B 8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
negative regulation of transcription by RNA polymerase II	IMP
positive regulation of transcription by galactose	IMP
regulation of transcription by RNA polymerase II	IEA
positive regulation of transcription by RNA polymerase II	IMP
positive regulation of transcription by RNA polymerase II	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

response to stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by galactose [inference]

positive regulation of transcription by galactose

regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by galactose [inference]

positive regulation of transcription by galactose

regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by galactose [inference]

positive regulation of transcription by galactose

regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by galactose [inference]

positive regulation of transcription by galactose

regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by galactose [inference]

positive regulation of transcription by galactose

regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by galactose [inference]

positive regulation of transcription by galactose

regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

carbon catabolite regulation of transcription [inference]

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

carbon catabolite activation of transcription [inference]

positive regulation of transcription by galactose

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IEA
mediator complex	IDA
mediator complex	IBA
mediator complex	IEA
CKM complex	IPI

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

mediator complex

nuclear cyclin-dependent protein kinase holoenzyme complex [inference]

CKM complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

serine/threonine protein kinase complex [inference]

cyclin-dependent protein kinase holoenzyme complex [inference]

nuclear cyclin-dependent protein kinase holoenzyme complex [inference]

CKM complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transcription coregulator activity	IEA
transcription coactivator activity	IDA
transcription coactivator activity	IMP
transcription coactivator activity	IBA

GO Hierarchy

molecular function

transcription regulator activity [inference]

transcription coregulator activity

transcription coactivator activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
mediator complex	PMID:11383511 PMID:12200444

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	9968	HGNC:11957

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026