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Guidelines

MIRAGE

mitochondrial 37S ribosomal protein mS47 EHD3

Summary

Gene Symbol

EHD3

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

851606

KEGG Gene ID

PubChem

851606

Alliance of Genome Resources

SGD:S000002443

Annotation

Keyword

3D-structure
Branched-chain amino acid catabolism
Hydrolase
Mitochondrion
Phosphoprotein
Reference proteome
Ribosomal protein

Proteins

Displaying 1 entry
UniProt	Protein Name
P28817	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 3-hydroxyisobutyryl-coenzyme A hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
L-valine catabolic process	IBA
mitochondrial translation	NAS
mitochondrial translation	IC

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-valine catabolic process

proteinogenic amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

protein metabolic process [inference]

translation [inference]

mitochondrial translation

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

L-valine catabolic process

branched-chain amino acid catabolic process [inference]

L-valine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

L-valine catabolic process

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

protein metabolic process [inference]

translation [inference]

mitochondrial translation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-valine catabolic process

proteinogenic amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

L-valine catabolic process

branched-chain amino acid catabolic process [inference]

L-valine catabolic process

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-valine catabolic process

proteinogenic amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

L-valine catabolic process

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

L-valine catabolic process

proteinogenic amino acid catabolic process [inference]

L-valine catabolic process

alpha-amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-valine catabolic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	IEA
mitochondrion	HDA
mitochondrial inner membrane	NAS

GO Hierarchy

cellular component

protein-containing complex [inference]

mitochondrial protein-containing complex [inference]

mitochondrial small ribosomal subunit

ribonucleoprotein complex [inference]

ribosomal subunit [inference]

small ribosomal subunit [inference]

organellar small ribosomal subunit [inference]

mitochondrial small ribosomal subunit

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
structural constituent of ribosome	IDA
catalytic activity	IEA
3-hydroxyisobutyryl-CoA hydrolase activity	IDA
3-hydroxyisobutyryl-CoA hydrolase activity	IBA
3-hydroxyisobutyryl-CoA hydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity [inference]

short-chain fatty acyl-CoA hydrolase activity [inference]

3-hydroxyisobutyryl-CoA hydrolase activity

deacylase activity [inference]

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity [inference]

short-chain fatty acyl-CoA hydrolase activity [inference]

3-hydroxyisobutyryl-CoA hydrolase activity

structural molecule activity [inference]

structural constituent of ribosome

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

3-hydroxyisobutyryl-CoA hydrolase

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
3-hydroxyisobutyryl-CoA hydrolase activity
catalytic activity
hydrolase activity
valine catabolic process

Displaying **all 4** entries
InterPro
ClpP/crotonase-like domain superfamily
Enoyl-CoA hydratase/isomerase domain
Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type
Enoyl-CoA hydratase/isomerase, conserved site

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
mitochondrial small ribosomal subunit	PMID:28154081
mitochondrion	PMID:14562095 PMID:14576278 PMID:16823961 PMID:17054397 PMID:24769239

Rhea

H₂O + 3-hydroxy-2-methylpropanoyl-CoA

3-hydroxy-2-methylpropanoate + H⁺ + CoA

Enzyme

3.1.2.4

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007310
Gene Name: Ehd3p

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	26275	HGNC:4908

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026