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translation termination factor GTPase eRF3

Summary

Gene Symbol

SUP35

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

851752

KEGG Gene ID

PubChem

851752

Alliance of Genome Resources

SGD:S000002579

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
GTP-binding
Hydrolase
Phosphoprotein
Prion
Protein biosynthesis
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P05453	ERF-3 ERF2 G1 to S phase transition protein 1 Omnipotent suppressor protein 2 PSI no more protein 2 Polypeptide release factor 3 Translation release factor 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IEA
translation	IBA
translational termination	IDA
translational termination	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

macromolecule biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

protein metabolic process [inference]

translation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

translational termination

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

translational termination

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

RNA destabilization [inference]

mRNA destabilization [inference]

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Displaying entries **1 - 5** of 9 in total

1

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GO Term	Evidence Code	PMID
cytoplasm	NAS
cytoplasm	IEA
cytosol	TAS
cytosol	HDA
cytoplasmic stress granule	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

translation release factor complex

cellular anatomical structure [inference]

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
mRNA binding	HDA
translation release factor activity	IDA
translation release factor activity	IBA
translation release factor activity	IEA
GTPase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

protein binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

translation factor activity [inference]

translation termination factor activity [inference]

translation release factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

elongation factor 1-alpha

Functional Category

J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
GTP binding
nucleotide binding

Displaying **all 7** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Tr-type G domain, conserved site
Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
Translation elongation factor EFTu-like, domain 2
Translation elongation factor EFTu/EF1A, C-terminal
Translation protein, beta-barrel domain superfamily
Translational (tr)-type GTP-binding domain

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
cytoplasmic stress granule	PMID:23451152
translation release factor complex	PMID:7556078
cytosol	PMID:26928762

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	23708	HGNC:4622
Homo sapiens	2935	HGNC:4621

GlyTouCan

GlyComb

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LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements