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alkaline phosphatase PHO8

Summary

Gene Symbol

PHO8

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852092

PubChem

852092

Alliance of Genome Resources

SGD:S000002889

Annotation

Keyword

Cytoplasm
Direct protein sequencing
Glycoprotein
Hydrolase
Magnesium
Metal-binding
Phosphoprotein
Reference proteome
Transmembrane helix
Vacuole
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P11491	Fructose-2,6-bisphosphate 6-phosphatase Membrane-bound repressible alkaline phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphate-containing compound metabolic process	IEA
nucleotide catabolic process	IMP	25468960
organophosphate metabolic process	IEA
nicotinamide nucleotide metabolic process	IMP	21349851

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic substance metabolic process [inference]

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
fungal-type vacuole membrane	IDA	2676517
fungal-type vacuole membrane	IBA
fungal-type vacuole membrane	HDA	26928762
cytoplasm	IEA
vacuole	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane

lytic vacuole membrane [inference]

fungal-type vacuole membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
alkaline phosphatase activity	IDA	8499492
alkaline phosphatase activity	IBA
alkaline phosphatase activity	IEA
zinc ion binding	RCA	30358795
hydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

alkaline phosphatase activity

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose-2,6-bisphosphate 6-phosphatase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alkaline phosphatase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
fungal-type vacuole membrane	PMID:2676517 PMID:26928762

Rhea

RHEA:15017

H₂O + a phosphate monoester

an alcohol + phosphate

Enzyme

PMID

RHEA:13333

H₂O + β-D-fructose 2,6-bisphosphate

phosphate + β-D-fructose 2-phosphate

Enzyme

3.1.3.54

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 18 in total

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DO ID	Disease Name	Source
DOID:0080001	bone disease	Alliance of Genome Resources
DOID:0110914	infantile hypophosphatasia	Alliance of Genome Resources
DOID:10573	osteomalacia	Alliance of Genome Resources
DOID:10609	rickets	Alliance of Genome Resources
DOID:11383	cryptorchidism	Alliance of Genome Resources
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:13994	cleidocranial dysplasia	Alliance of Genome Resources
DOID:14213	hypophosphatasia	Alliance of Genome Resources
DOID:182	calcinosis	Alliance of Genome Resources
DOID:2994	germ cell cancer	Alliance of Genome Resources

Ortholog

Displaying **all 10** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	248	Xenbase:XB-GENE-854726
Xenopus tropicalis	249	Xenbase:XB-GENE-1010301
Xenopus tropicalis	250	Xenbase:XB-GENE-854726
Xenopus tropicalis	251	Xenbase:XB-GENE-854726
Xenopus tropicalis	11647	Xenbase:XB-GENE-1010301
Xenopus tropicalis	11650	Xenbase:XB-GENE-854726
Xenopus tropicalis	25586	Xenbase:XB-GENE-1010301
Xenopus tropicalis	43671	Xenbase:XB-GENE-1010301
Xenopus tropicalis	76768	Xenbase:XB-GENE-854726
Xenopus tropicalis	852092	Xenbase:XB-GENE-854726

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LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements