GlyCosmos Portal

Annotation

Keyword

3D-structure
Autocatalytic cleavage
Hydrolase
Membrane
Nuclear pore complex
Phosphoprotein
RNA-binding
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P49687	Nuclear pore protein NUP145

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IMP
post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IBA
double-strand break repair	IMP
RNA export from nucleus	IBA
mRNA export from nucleus	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

intercellular transport [inference]

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA export from nucleus

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA export from nucleus

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

localization within membrane [inference]

nuclear pore localization

protein localization to membrane [inference]

protein localization to nuclear inner membrane

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

heterochromatin organization [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

organelle organization [inference]

nucleus organization [inference]

nuclear pore localization

chromosome organization [inference]

transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [inference]

post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery

cellular component assembly [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

protein localization to nuclear envelope [inference]

protein localization to nuclear inner membrane

protein localization to membrane [inference]

protein localization to nuclear inner membrane

protein-containing complex localization [inference]

nuclear pore localization

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA export from nucleus

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA export from nucleus

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA transport [inference]

tRNA export from nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA export from nucleus

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA transport [inference]

tRNA export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA export from nucleus

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

organelle localization [inference]

chromosome localization [inference]

telomere localization [inference]

telomere tethering at nuclear periphery

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

poly(A)+ mRNA export from nucleus

tRNA export from nucleus

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

localization within membrane [inference]

nuclear pore localization

protein localization to membrane [inference]

protein localization to nuclear inner membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

constitutive heterochromatin formation [inference]

subtelomeric heterochromatin formation

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IEA
nuclear pore	NAS
nuclear pore	IDA
nuclear pore	IEA
nuclear pore outer ring	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

nuclear membrane

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
RNA binding	IDA
RNA binding	IBA
protein binding	IPI
nuclear localization sequence binding	IBA
hydrolase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

structural molecule activity [inference]

structural constituent of nuclear pore

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding

peptide binding [inference]

signal sequence binding [inference]

nuclear localization sequence binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nuclear pore complex

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
RNA export from nucleus
mRNA transport
nuclear localization sequence binding
post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
protein import into nucleus
telomere tethering at nuclear periphery

Displaying **all 4** entries
InterPro
Nuclear pore complex protein NUP96, C-terminal domain
Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily
Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain
Nucleoporin peptidase S59-like

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
nuclear pore central transport channel	PMID:18046406
nuclear pore	PMID:10684247
nuclear pore outer ring	PMID:11823431 PMID:18046406 PMID:9305650

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements