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cleavage polyadenylation factor subunit MPE1

Summary

Gene Symbol

MPE1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

853806

KEGG Gene ID

PubChem

853806

Alliance of Genome Resources

SGD:S000001542

Annotation

Keyword

3D-structure
Nucleus
Phosphoprotein
Reference proteome
Zinc-finger
mRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
P35728

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein polyubiquitination	IMP
termination of RNA polymerase II transcription	IDA
mRNA processing	IEA
ubiquitin-dependent protein catabolic process	IBA
protein ubiquitination	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription termination [inference]

termination of RNA polymerase II transcription

termination of RNA polymerase II transcription, poly(A)-coupled

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription termination [inference]

termination of RNA polymerase II transcription

termination of RNA polymerase II transcription, poly(A)-coupled

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription termination [inference]

termination of RNA polymerase II transcription

termination of RNA polymerase II transcription, poly(A)-coupled

protein metabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

mRNA processing

RNA biosynthetic process [inference]

DNA-templated transcription termination [inference]

termination of RNA polymerase II transcription

termination of RNA polymerase II transcription, poly(A)-coupled

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription termination [inference]

termination of RNA polymerase II transcription

termination of RNA polymerase II transcription, poly(A)-coupled

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription termination [inference]

termination of RNA polymerase II transcription

termination of RNA polymerase II transcription, poly(A)-coupled

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

mRNA processing

RNA biosynthetic process [inference]

DNA-templated transcription termination [inference]

termination of RNA polymerase II transcription

termination of RNA polymerase II transcription, poly(A)-coupled

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription termination [inference]

termination of RNA polymerase II transcription

termination of RNA polymerase II transcription, poly(A)-coupled

RNA processing [inference]

mRNA processing

protein metabolic process [inference]

protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	NAS
nucleus	IDA
nucleus	IBA
nucleus	IEA
cytosol	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

mRNA cleavage factor complex [inference]

mRNA cleavage and polyadenylation specificity factor complex

cellular anatomical structure [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA
protein binding	IPI
zinc ion binding	RCA
zinc ion binding	IEA
pre-mRNA binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

nucleic acid binding

RNA binding [inference]

pre-mRNA binding

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

e3 ubiquitin-protein ligase RBBP6

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
metal ion binding
protein ubiquitination
zinc ion binding

Displaying **all 5** entries
InterPro
DWNN domain
Zinc finger, CCHC-type superfamily
Zinc finger, CCHC-type
Zinc finger, RING/FYVE/PHD-type
Zinc knuckle CX2CX3GHX4C

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
mRNA cleavage and polyadenylation specificity factor complex	PMID:12819204
cytosol	PMID:22932476
nucleus	PMID:22932476 PMID:35584695

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:162	cancer	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	19647	MGI:894835
Homo sapiens	5930	HGNC:9889

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026

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