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alkylglycerone phosphate synthase

Summary

Gene Symbol

AGPS

Aliases

ADAP-S
ADAS
ADHAPS
ADPS
ALDHPSY

Organism

Homo sapiens (human)

External Links

NCBI Gene

8540

HGNC

327

KEGG Gene ID

hsa:8540

PubChem

8540

Alliance of Genome Resources

HGNC:327

JoGo

AGPS

TogoVar

AGPS

Annotation

Keyword

Acetylation
Cataract
Disease variant
Dwarfism
FAD
Lipid biosynthesis
Membrane
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome
Rhizomelic chondrodysplasia punctata
Transferase
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O00116	Aging-associated gene 5 protein Alkylglycerone-phosphate synthase
B7Z3Q4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lipid biosynthetic process	IDA
lipid biosynthetic process	IBA
lipid biosynthetic process	IEA
ether lipid biosynthetic process	ISS
ether lipid biosynthetic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process

ether lipid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
mitochondrion	HDA
peroxisome	ISS
peroxisome	IDA
peroxisome	IBA
peroxisome	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
catalytic activity	IEA
protein binding	IPI
alkylglycerone-phosphate synthase activity	IDA
alkylglycerone-phosphate synthase activity	IBA
alkylglycerone-phosphate synthase activity	IEA

GO Hierarchy

molecular function

catalytic activity

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

alkylglycerone-phosphate synthase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

FAD binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

FAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

d-lactate dehydrogenase

Functional Category

C: Energy production and conversion
H: Coenzyme transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
D-lactate dehydrogenase (cytochrome) activity
D-lactate dehydrogenase activity
FAD binding
catalytic activity
flavin adenine dinucleotide binding
lactate catabolic process

Displaying **all 7** entries
InterPro
FAD linked oxidase, N-terminal
FAD-binding domain, PCMH-type
FAD-binding oxidoreductase/transferase, type 4, C-terminal
FAD-binding, type PCMH, subdomain 2
FAD-binding, type PCMH-like superfamily
FAD-linked oxidase-like, C-terminal
Vanillyl-alcohol oxidase, C-terminal subdomain 2

Human Protein Atlas

ENSG00000018510

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00803

Name

alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]

References

Rhea

RHEA:36171

a long chain fatty alcohol + a 1-acylglycerone 3-phosphate

H⁺ + a long-chain fatty acid + 1-O-alkylglycerone 3-phosphate

Enzyme

2.5.1.26

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110853	rhizomelic chondrodysplasia punctata type 3	Alliance of Genome Resources
DOID:2580	rhizomelic chondrodysplasia punctata	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 7** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0001508	Failure to thrive
HP:0003097	Short femur
HP:0005792	Short humerus
HP:0008873	Disproportionate short-limb short stature
HP:0008905	Rhizomelia
HP:0010655	Epiphyseal stippling