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solute carrier family 5 member 7

Summary

Gene Symbol

Slc5a7

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

85426

KEGG Gene ID

PubChem

85426

Alliance of Genome Resources

RGD:69270

Annotation

Keyword

Cell membrane
Cell projection
Cytoplasmic vesicle
Endosome
Glycoprotein
Neurotransmitter biosynthesis
Phosphoprotein
Reference proteome
Sodium transport
Symport
Synapse
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6KQA3	Hemicholinium-3-sensitive choline transporter Solute carrier family 5 member 7
Q9JMD7	Hemicholinium-3-sensitive choline transporter Solute carrier family 5 member 7
G3V7G1	Hemicholinium-3-sensitive choline transporter Solute carrier family 5 member 7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	ISO
sodium ion transport
synaptic transmission, cholinergic	ISO
synaptic transmission, cholinergic	IBA
neuromuscular synaptic transmission	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

biosynthetic process [inference]

acetylcholine biosynthetic process

transmembrane transport

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

organic cation transport [inference]

choline transport

transmembrane transport

nitrogen compound transport [inference]

choline transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
early endosome	IDA
plasma membrane	ISO
plasma membrane	IBA
synaptic vesicle	IDA
membrane	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

cell junction [inference]

synapse

neuromuscular junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

presynapse

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
choline:sodium symporter activity	ISS
choline:sodium symporter activity	ISO
choline:sodium symporter activity	EXP
choline:sodium symporter activity	IBA
protein binding	IPI

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

choline transmembrane transporter activity

choline:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

choline binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

high affinity choline transporter 1

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
acetylcholine biosynthetic process
choline transport
choline
monoatomic ion transport
symporter activity

Displaying **all 2** entries
InterPro
Sodium/glucose symporter superfamily
Sodium/solute symporter

Alliance of Genome Resources

Expression

Displaying **all 8** entries
Location	References
early endosome	PMID:15953352
perikaryon	PMID:11904763
synaptic vesicle	PMID:20394050
dendrite	PMID:11904763
axon	PMID:11904763
plasma membrane raft	PMID:24127780
clathrin-coated endocytic vesicle	PMID:15953352
apical plasma membrane	PMID:12628461

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	63993	MGI:1927126
Caenorhabditis elegans	178274	WB:WBGene00000501
Drosophila melanogaster	42245	FB:FBgn0038641
Homo sapiens	60482	HGNC:14025

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OrthoDB (Group)

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Acknowledgements