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cyclin dependent kinase 13
Summary
- Gene Symbol
-
- CDK13
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Disease variant
- Host-virus interaction
- Intellectual disability
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Proteomics identification
- RNA editing
- Reference proteome
- Serine/threonine-protein kinase
- Ubl conjugation
- mRNA splicing
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| alternative mRNA splicing, via spliceosome | ||
| alternative mRNA splicing, via spliceosome | ||
| regulation of signal transduction | ||
| hemopoiesis | ||
| positive regulation of transcription elongation by RNA polymerase II |
GO Hierarchy
- regulation of cell cycle
biological process
biological regulation [inference]
regulation of biological process [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cyclin K-CDK13 complex | ||
| extracellular region | ||
| obsolete extracellular space | ||
| nucleus | ||
| nucleoplasm |
| GO Term | Evidence Code | PMID |
|---|---|---|
| RNA binding | ||
| protein kinase activity | ||
| cyclin-dependent protein serine/threonine kinase activity | ||
| protein binding | ||
| ATP binding |
GO Hierarchy
- cyclin-dependent protein serine/threonine kinase activity
- RNA polymerase II CTD heptapeptide repeat Y1 kinase activity
- RNA polymerase II CTD heptapeptide repeat S2 kinase activity
- RNA polymerase II CTD heptapeptide repeat T4 kinase activity
- RNA polymerase II CTD heptapeptide repeat S5 kinase activity
- RNA polymerase II CTD heptapeptide repeat S7 kinase activity
- protein serine kinase activity
- cyclin-dependent protein serine/threonine kinase activity
- RNA polymerase II CTD heptapeptide repeat Y1 kinase activity
- RNA polymerase II CTD heptapeptide repeat S2 kinase activity
- RNA polymerase II CTD heptapeptide repeat T4 kinase activity
- RNA polymerase II CTD heptapeptide repeat S5 kinase activity
- RNA polymerase II CTD heptapeptide repeat S7 kinase activity
- protein serine kinase activity
- cyclin-dependent protein serine/threonine kinase activity
- RNA polymerase II CTD heptapeptide repeat Y1 kinase activity
- RNA polymerase II CTD heptapeptide repeat S2 kinase activity
- RNA polymerase II CTD heptapeptide repeat T4 kinase activity
- RNA polymerase II CTD heptapeptide repeat S5 kinase activity
- RNA polymerase II CTD heptapeptide repeat S7 kinase activity
- protein serine kinase activity
- RNA polymerase II CTD heptapeptide repeat Y1 kinase activity
- RNA polymerase II CTD heptapeptide repeat S2 kinase activity
- RNA polymerase II CTD heptapeptide repeat T4 kinase activity
- RNA polymerase II CTD heptapeptide repeat S5 kinase activity
- RNA polymerase II CTD heptapeptide repeat S7 kinase activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
kinase activity [inference]
protein kinase activity
protein serine/threonine kinase activity [inference]
RNA polymerase II CTD heptapeptide repeat kinase activity
phosphotransferase activity, alcohol group as acceptor [inference]
protein kinase activity
protein serine/threonine kinase activity [inference]
RNA polymerase II CTD heptapeptide repeat kinase activity
catalytic activity, acting on a protein [inference]
protein kinase activity
protein serine/threonine kinase activity [inference]
RNA polymerase II CTD heptapeptide repeat kinase activity
RNA polymerase II CTD heptapeptide repeat modifying activity [inference]
RNA polymerase II CTD heptapeptide repeat kinase activity
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Cyclin-dependent kinase 12
- Functional Category
-
- G: Carbohydrate transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| RNA polymerase II CTD heptapeptide repeat kinase activity |
| cyclin binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| transferase activity |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase, ATP binding site |
| Protein kinase-like domain superfamily |
| Serine/threonine-protein kinase, active site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0112247 | congenital heart defects, dysmorphic facial features, and intellectual developmental disorder | |
| DOID:10286 | prostate carcinoma | |
| DOID:1059 | intellectual disability | |
| DOID:684 | hepatocellular carcinoma |
