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sphingosine-1-phosphate receptor 4

Summary

Gene Symbol

S1PR4

Organism

Homo sapiens (human)

External Links

NCBI Gene

8698

PubChem

8698

Alliance of Genome Resources

HGNC:3170

Annotation

Keyword

3D-structure
Cell membrane
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O95977	Endothelial differentiation G-protein coupled receptor 6 Sphingosine 1-phosphate receptor Edg-6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
sphingosine-1-phosphate receptor signaling pathway	IEA
immune response
G protein-coupled receptor signaling pathway	IDA	9790765
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
positive regulation of cytosolic calcium ion concentration

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
mitochondrion	IDA
plasma membrane	TAS
plasma membrane	IBA
presynapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

presynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IBA
protein binding	IPI	32296183
lipid binding	TAS	10679247
sphingosine-1-phosphate receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

bioactive lipid receptor activity [inference]

sphingosine-1-phosphate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sphingosine 1-phosphate receptor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
sphingosine-1-phosphate receptor activity

Displaying **all 4** entries
InterPro
EDG-6 sphingosine 1-phosphate receptor
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Sphingosine 1-phosphate receptor

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8698	Xenbase:XB-GENE-988208
Mus musculus	13611	Xenbase:XB-GENE-988208	MOUSE02978
Rattus norvegicus	314649		RATNO37691
Danio rerio	402857		DANRE22993
Macaca mulatta	712637		MACMU19458
Macaca mulatta	712703		MACMU19458
Monodelphis domestica	100010030		MONDO18281
Taeniopygia guttata	100228150		TAEGU15867
Pongo abelii	100460707		PONAB15473
Anolis carolinensis	100565734		ANOCA12280