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succinate-CoA ligase ADP-forming subunit beta

Summary

Gene Symbol

SUCLA2

Aliases

succinate--CoA ligase (ADP-forming)

Organism

Homo sapiens (human)

External Links

NCBI Gene

8803

HGNC

11448

KEGG Gene ID

hsa:8803

PubChem

8803

Alliance of Genome Resources

HGNC:11448

JoGo

SUCLA2

TogoVar

SUCLA2

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Disease variant
Ligase
Magnesium
Metal-binding
Mitochondrion
Phosphoprotein
Primary mitochondrial disease
Proteomics identification
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E5KS60	ATP-specific succinyl-CoA synthetase subunit beta Succinyl-CoA synthetase beta-A chain
Q9P2R7	ATP-specific succinyl-CoA synthetase subunit beta Itaconyl--CoA ligase [ADP-forming] subunit beta Malyl--CoA ligase [ADP-forming] subunit beta Succinyl-CoA synthetase beta-A chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
tricarboxylic acid cycle	NAS
tricarboxylic acid cycle	IBA
tricarboxylic acid cycle	IEA
succinyl-CoA metabolic process	TAS
succinyl-CoA metabolic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

sulfur compound catabolic process [inference]

succinyl-CoA catabolic process

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside phosphate catabolic process [inference]

succinyl-CoA catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

succinyl-CoA catabolic process

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

succinyl-CoA catabolic process

sulfur compound catabolic process [inference]

succinyl-CoA catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

succinyl-CoA catabolic process

purine-containing compound catabolic process [inference]

succinyl-CoA catabolic process

biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

succinyl-CoA pathway

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

succinyl-CoA pathway

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

succinyl-CoA pathway

primary metabolic process [inference]

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

succinyl-CoA catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside phosphate catabolic process [inference]

succinyl-CoA catabolic process

small molecule metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

nucleoside phosphate catabolic process [inference]

succinyl-CoA catabolic process

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

purine-containing compound catabolic process [inference]

succinyl-CoA catabolic process

metabolite repair [inference]

toxic metabolite repair

cellular detoxification [inference]

toxic metabolite repair

detoxification [inference]

cellular detoxification [inference]

toxic metabolite repair

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GO Term	Evidence Code	PMID
cytoplasm	IEA
mitochondrion	EXP
mitochondrion	NAS
mitochondrion	IDA
mitochondrion	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

tricarboxylic acid cycle heteromeric enzyme complex [inference]

succinate-CoA ligase complex

succinate-CoA ligase complex (ADP-forming)

cellular anatomical structure [inference]

cytoplasm

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
succinate-CoA ligase (ADP-forming) activity	IEA
protein binding	IPI
ATP binding	IEA
acid-thiol ligase activity	IDA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity

ligase activity [inference]

ligase activity, forming carbon-sulfur bonds [inference]

acid-thiol ligase activity

CoA-ligase activity [inference]

succinate-CoA ligase activity [inference]

succinate-CoA ligase (ADP-forming) activity

malate-CoA ligase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000136143

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:17661

succinate + ATP + CoA

phosphate + ADP + succinyl-CoA

Enzyme

6.2.1.5

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080124	mitochondrial DNA depletion syndrome 5	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000365	Hearing impairment
HP:0000407	Sensorineural hearing impairment
HP:0000486	Strabismus
HP:0000505	Visual impairment
HP:0000508	Ptosis
HP:0000512	Abnormal electroretinogram
HP:0000602	Ophthalmoplegia
HP:0000649	Abnormality of visual evoked potentials

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:1933	mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria
OMIM:612073	mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria