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dolichyl-phosphate mannosyltransferase subunit 1, catalytic

Summary

Gene Symbol

DPM1

Aliases

CDGIE
DPM synthase complex, catalytic subunit
MPDS

Organism

Homo sapiens (human)

External Links

NCBI Gene

8813

GGDB ID

gg140

HGNC

3005

mRNA

NM_003859

map

20q13.13

Protein

NP_003850

OMIM

603503

KEGG Gene ID

hsa:8813

PubChem

8813

Alliance of Genome Resources

HGNC:3005

JoGo

DPM1

TogoVar

DPM1

Annotation

Keyword

Acetylation
Congenital disorder of glycosylation
Congenital muscular dystrophy
Disease variant
Dystroglycanopathy
Endoplasmic reticulum
Glycosyltransferase
Magnesium
Manganese
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
O60762	Dolichol-phosphate mannose synthase subunit 1 Dolichyl-phosphate beta-D-mannosyltransferase subunit 1 Mannose-P-dolichol synthase subunit 1
Q5QPK2
A0A0S2Z4Y5
H0Y368

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
dolichol-linked oligosaccharide biosynthetic process	TAS
dolichol-linked oligosaccharide biosynthetic process	IBA
GPI anchor biosynthetic process	IDA
GPI anchor biosynthetic process	IGI
GPI anchor biosynthetic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl monophosphate biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

dolichol phosphate mannose biosynthetic process

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-mannose metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl monophosphate biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

dolichol phosphate mannose biosynthetic process

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-mannose metabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl monophosphate biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

dolichol phosphate mannose biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl monophosphate biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

dolichol phosphate mannose biosynthetic process

glycolipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl monophosphate biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

dolichol phosphate mannose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

glycolipid biosynthetic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-mannose metabolic process

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl monophosphate biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

dolichol phosphate mannose biosynthetic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

terpenoid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

dolichol phosphate mannose biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl monophosphate biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

dolichol phosphate mannose biosynthetic process

glycolipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-mannose metabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

nucleotide-sugar metabolic process [inference]

GDP-mannose metabolic process

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

glycolipid biosynthetic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

response to stimulus [inference]

response to abiotic stimulus [inference]

response to oxygen levels

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	HDA
endoplasmic reticulum	IDA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	NAS
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

mannosyltransferase complex [inference]

dolichol-phosphate-mannose synthase complex

catalytic complex [inference]

transferase complex [inference]

mannosyltransferase complex [inference]

dolichol-phosphate-mannose synthase complex

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

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GO Term	Evidence Code	PMID
dolichyl-phosphate beta-D-mannosyltransferase activity	EXP
dolichyl-phosphate beta-D-mannosyltransferase activity	IDA
dolichyl-phosphate beta-D-mannosyltransferase activity	IGI
dolichyl-phosphate beta-D-mannosyltransferase activity	IBA
dolichyl-phosphate beta-D-mannosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity [inference]

dolichyl-phosphate beta-D-mannosyltransferase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

D-mannose binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

alcohol binding

monosaccharide binding [inference]

D-mannose binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000000419

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg140

Gene Symbol

DPM1

Orthologous Gene

Displaying **all 6** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_499931	NM_067530
Mus musculus	NP_034202	NM_010072
Saccharomyces cerevisiae	AAA34578	J04184
Drosophila melanogaster	NP_609980	NM_136136
Rattus norvegicus	XP_215949	XM_215949
Arabidopsis thaliana	NP_564118	NM_101908

KEGG BRITE Database

Orthology

K00721

Name

dolichol-phosphate mannosyltransferase [EC:2.4.1.83]

References

3053713

Rhea

RHEA:21184

GDP-α-D-mannose

GDP

Enzyme

2.4.1.83

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080557	congenital disorder of glycosylation Ie	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000243	Trigonocephaly
HP:0000293	Full cheeks
HP:0000316	Hypertelorism
HP:0000319	Smooth philtrum
HP:0000347	Micrognathia
HP:0000486	Strabismus
HP:0000488	Retinopathy
HP:0000494	Downslanted palpebral fissures
HP:0000565	Esotropia

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:608799	congenital disorder of glycosylation type 1E
ORPHA:79322	congenital disorder of glycosylation type 1E

PubChem Disease

MedGen Diseases

Congenital disorder of glycosylation type 1E

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ie; CDG1E

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP004810
Gene Name: dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

Ortholog

Displaying **all 9** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13480	MGI:1330239
Rattus norvegicus	296394	RGD:1310120
Caenorhabditis elegans	176874	WB:WBGene00022044
Drosophila melanogaster	35240	FB:FBgn0032799
Saccharomyces cerevisiae S288C	856313	SGD:S000006387
Danio rerio	445202	ZFIN:ZDB-GENE-040801-115
Xenopus laevis	414689	Xenbase:XB-GENE-17330542
Xenopus laevis	734516	Xenbase:XB-GENE-976628
Xenopus tropicalis	496884	Xenbase:XB-GENE-976623

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements