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IQ motif containing GTPase activating protein 1

Summary

Gene Symbol

IQGAP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

8826

PubChem

8826

Alliance of Genome Resources

HGNC:6110

JoGo

IQGAP1

TogoVar

IQGAP1

Annotation

Keyword

3D-structure
Acetylation
Calmodulin-binding
Cell membrane
Coiled coil
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0J9YXZ5
P46940	p195

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
MAPK cascade	IEA
regulation of cytokine production
signal transduction	TAS
epidermal growth factor receptor signaling pathway	IMP
epidermal growth factor receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade

cell cycle process [inference]

mitotic cell cycle process [inference]

mitotic actomyosin contractile ring assembly actin filament organization

actomyosin contractile ring assembly actin filament organization [inference]

mitotic actomyosin contractile ring assembly actin filament organization

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

fibroblast migration

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

membrane assembly [inference]

membrane raft assembly [inference]

plasma membrane raft assembly [inference]

caveola assembly

membrane organization [inference]

membrane raft organization [inference]

membrane raft assembly [inference]

plasma membrane raft assembly [inference]

caveola assembly

plasma membrane raft organization [inference]

plasma membrane raft assembly [inference]

caveola assembly

membrane assembly [inference]

membrane raft assembly [inference]

plasma membrane raft assembly [inference]

caveola assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actomyosin contractile ring assembly actin filament organization [inference]

mitotic actomyosin contractile ring assembly actin filament organization

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

response to platelet-derived growth factor [inference]

cellular response to platelet-derived growth factor stimulus

response to epidermal growth factor [inference]

cellular response to epidermal growth factor stimulus

cellular response to growth factor stimulus [inference]

response to fibroblast growth factor [inference]

cellular response to fibroblast growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

response to chemical [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

MAPK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

regulation of dephosphorylation [inference]

negative regulation of dephosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of cell cycle [inference]

regulation of mitotic cell cycle

regulation of multicellular organismal process [inference]

regulation of cytokine production

Displaying entries **1 - 5** of 42 in total

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GO Term	Evidence Code	PMID
ruffle	IDA
nucleus	IDA
nucleus	IBA
nucleus	IEA
cytoplasm	EXP

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex

cellular anatomical structure [inference]

cytoplasm

cell cortex

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

plasma membrane region [inference]

lateral plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction

filtration diaphragm [inference]

slit diaphragm

cell-substrate junction [inference]

focal adhesion

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection

ruffle

neuron projection

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
MAP kinase scaffold activity	IPI
GTPase inhibitor activity	TAS
GTPase inhibitor activity	IEA
GTPase activator activity	TAS
GTPase activator activity	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

protein complex scaffold activity [inference]

MAP kinase scaffold activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

phosphatase binding [inference]

protein phosphatase binding

GTPase binding [inference]

small GTPase binding

cell adhesion molecule binding [inference]

cadherin binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

actin filament binding

molecular adaptor activity

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

MAP kinase scaffold activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

GTPase inhibitor activity

enzyme activator activity [inference]

GTPase activator activity

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

GTPase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ras GTPase-activating-like protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
actin filament binding
calmodulin binding
mitotic actomyosin contractile ring assembly actin filament organization

Displaying **all 6** entries
InterPro
CH domain superfamily
Calponin homology domain
IQ motif, EF-hand binding site
Ras GTPase-activating domain
RasGAP protein, C-terminal
Rho GTPase activation protein

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements