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MIRAGE
sphingosine-1-phosphate lyase 1
Summary
- Gene Symbol
-
- SGPL1
- Aliases
-
- SPL
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Apoptosis
- Disease variant
- Endoplasmic reticulum
- Lyase
- Nitration
- Phosphoprotein
- Proteomics identification
- Pyridoxal phosphate
- Reference proteome
- Signal-anchor
- Sphingolipid metabolism
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| O95470 |
|
| A0A8V8TN35 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| roof of mouth development | ||
| face morphogenesis | ||
| apoptotic signaling pathway |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum | ||
| endoplasmic reticulum | ||
| endoplasmic reticulum membrane | ||
| endoplasmic reticulum membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| sphinganine-1-phosphate aldolase activity | ||
| sphinganine-1-phosphate aldolase activity | ||
| sphinganine-1-phosphate aldolase activity | ||
| sphinganine-1-phosphate aldolase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- sphingosine-1-phosphate lyase
- Functional Category
-
- E: Amino acid transport and metabolism
- H: Coenzyme transport and metabolism
- J: Translation, ribosomal structure and biogenesis
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080265 | nephrotic syndrome type 14 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001888 | Lymphopenia |
| HP:0001943 | Hypoglycemia |
| HP:0001967 | Diffuse mesangial sclerosis |
| HP:0002155 | Hypertriglyceridemia |
| HP:0002376 | Developmental regression |
| HP:0003073 | Hypoalbuminemia |
| HP:0003593 | Infantile onset |
| HP:0003621 | Juvenile onset |
| HP:0003676 | Progressive |
| HP:0003774 | Stage 5 chronic kidney disease |
| Disease ID | Disease Name |
|---|---|
| OMIM:617575 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000574
- Gene Name
- sphingosine-1-phosphate lyase 1
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100072755 | HORSE18000 | ||
| 100077675 | ORNAN18186 | ||
| 100173995 | PONAB01472 | ||
| 100224512 | TAEGU26726 | ||
| 100403731 | CALJA07601 | ||
| 100473418 | AILME18318 | ||
| 100525187 | PIGXX07757 | ||
| 100545432 | MELGA12461 | ||
| 100565427 | ANOCA04336 | ||
| 100590433 | NOMLE14726 |
