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cell division cycle 16

Summary

Gene Symbol

CDC16

Organism

Homo sapiens (human)

External Links

NCBI Gene

8881

KEGG Gene ID

PubChem

8881

Alliance of Genome Resources

HGNC:1720

Annotation

Keyword

3D-structure
Alternative splicing
Cytoskeleton
Mitosis
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
TPR repeat
Ubl conjugation pathway

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q13042	Anaphase-promoting complex subunit 6 CDC16 homolog Cyclosome subunit 6
B2RCW0
A0A3B3ISD2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
regulation of mitotic cell cycle	NAS
protein ubiquitination	IBA
protein ubiquitination	IEA
anaphase-promoting complex-dependent catabolic process	NAS
anaphase-promoting complex-dependent catabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

anaphase-promoting complex-dependent catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

cell division

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of metaphase/anaphase transition of cell cycle [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of metaphase/anaphase transition of cell cycle [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of metaphase/anaphase transition of cell cycle [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of cell cycle [inference]

regulation of mitotic cell cycle

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of metaphase/anaphase transition of cell cycle [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of chromosome separation [inference]

regulation of mitotic sister chromatid separation [inference]

positive regulation of mitotic sister chromatid separation [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of metaphase/anaphase transition of cell cycle [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of metaphase/anaphase transition of cell cycle [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of metaphase/anaphase transition of cell cycle [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of metaphase/anaphase transition of cell cycle [inference]

positive regulation of mitotic metaphase/anaphase transition

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation [inference]

positive regulation of mitotic metaphase/anaphase transition

regulation of meiotic cell cycle

regulation of reproductive process [inference]

regulation of meiotic cell cycle

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
nucleoplasm	TAS
anaphase-promoting complex	NAS
anaphase-promoting complex	IDA
anaphase-promoting complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear ubiquitin ligase complex [inference]

anaphase-promoting complex

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

nuclear ubiquitin ligase complex [inference]

anaphase-promoting complex

cullin-RING ubiquitin ligase complex [inference]

anaphase-promoting complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

nuclear ubiquitin ligase complex [inference]

anaphase-promoting complex

cullin-RING ubiquitin ligase complex [inference]

anaphase-promoting complex

cellular anatomical structure [inference]

microtubule organizing center [inference]

centrosome

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

spindle

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

spindle

mitotic spindle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI
enzyme-substrate adaptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

enzyme-substrate adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

anaphase-promoting complex subunit

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cell division
positive regulation of mitotic metaphase/anaphase transition
protein ubiquitination

Displaying **all 2** entries
InterPro
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	853846	SGD:S000001505

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Last updated: April 6, 2026

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Acknowledgements