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Guidelines

MIRAGE

actinin alpha 2

Summary

Gene Symbol

ACTN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

88

KEGG Gene ID

PubChem

88

Alliance of Genome Resources

HGNC:164

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Calcium
Cardiomyopathy
Cytoplasm
Disease variant
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P35609	Alpha-actinin skeletal muscle isoform 2 F-actin cross-linking protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
cell adhesion	TAS
microspike assembly	IDA
actin cytoskeleton organization	IBA
regulation of membrane potential	IMP
regulation of apoptotic process	NAS

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

sarcomere organization

postsynaptic actin cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

muscle cell development

striated muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

actomyosin structure organization [inference]

sarcomere organization

postsynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

plasma membrane bounded cell projection organization [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

supramolecular fiber organization

developmental process [inference]

anatomical structure formation involved in morphogenesis

anatomical structure development [inference]

cell development [inference]

muscle cell development

striated muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development

striated muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of protein localization to cell surface [inference]

negative regulation of protein localization to cell surface

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of monoatomic ion transport [inference]

negative regulation of potassium ion transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of potassium ion transport

regulation of vesicle-mediated transport [inference]

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of potassium ion transport

negative regulation of protein localization [inference]

negative regulation of protein localization to cell surface

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of protein-containing complex disassembly [inference]

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of endocytic recycling

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

regulation of vesicle-mediated transport [inference]

regulation of endocytic recycling [inference]

positive regulation of endocytic recycling

regulation of biological quality [inference]

regulation of membrane potential

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament depolymerization [inference]

positive regulation of actin filament depolymerization [inference]

actin filament uncapping

Displaying entries **6 - 10** of 28 in total

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GO Term	Evidence Code	PMID
focal adhesion	IMP
focal adhesion	IEA
actin cytoskeleton	IEA
sarcomere	IEA
Z disc	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

glutamatergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

cell projection

plasma membrane bounded cell projection [inference]

pseudopodium

neuron projection [inference]

neuron spine [inference]

dendritic spine

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

actin cytoskeleton

postsynaptic actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

intracellular organelle [inference]

intracellular membraneless organelle [inference]

actin cytoskeleton

postsynaptic actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynapse [inference]

dendritic spine

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
transcription coactivator activity	IEA
integrin binding	TAS
integrin binding	IEA
calcium ion binding	IEA
protein binding	IPI

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton [inference]

structural constituent of postsynaptic actin cytoskeleton

structural constituent of muscle

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic actin cytoskeleton

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cytoskeletal protein binding

actin binding [inference]

actin filament binding

protein domain specific binding

cell adhesion molecule binding [inference]

integrin binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

molecular function regulator activity [inference]

molecular function activator activity [inference]

transporter activator activity [inference]

channel activator activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel activator activity

transporter activator activity [inference]

channel activator activity

transcription regulator activity [inference]

transcription coregulator activity [inference]

transcription coactivator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha actinin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
actin binding
actin cytoskeleton organization
actin filament binding
calcium ion binding

Displaying **all 8** entries
InterPro
Actinin-type actin-binding domain, conserved site
CH domain superfamily
Calponin homology domain
EF-hand domain pair
EF-hand domain
EF-hand, Ca insensitive
Spectrin repeat
Spectrin/alpha-actinin

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110428	dilated cardiomyopathy 1AA	Alliance of Genome Resources
DOID:0050431	arrhythmogenic right ventricular cardiomyopathy	Alliance of Genome Resources
DOID:0081342	congenital myopathy 8	Alliance of Genome Resources

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11472	MGI:109192

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Last updated: April 6, 2026