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calcium voltage-gated channel subunit alpha1 H

Summary

Gene Symbol

CACNA1H

Organism

Homo sapiens (human)

External Links

NCBI Gene

8912

KEGG Gene ID

PubChem

8912

Alliance of Genome Resources

HGNC:1395

Annotation

Keyword

3D-structure
Alternative splicing
Calcium channel
Cell membrane
Coiled coil
Disease variant
Epilepsy
Glycoprotein
Metal-binding
Proteomics identification
Reference proteome
Repeat
Transmembrane helix
Voltage-gated channel
Zinc

Proteins

Displaying **all 7** entries
UniProt	Protein Name
A0A1W2PQW2
B3KQH9
A0AAA9YHH8	Voltage-gated calcium channel subunit alpha Cav3.2
H3BUA8	Voltage-gated calcium channel subunit alpha Cav3.2
O95180	Low-voltage-activated calcium channel alpha1 3.2 subunit Voltage-gated calcium channel subunit alpha Cav3.2
H3BNT0	Voltage-gated calcium channel subunit alpha Cav3.2
H3BMW6	Voltage-gated calcium channel subunit alpha Cav3.2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
monoatomic ion transport	IEA
ion transport	IEA
muscle contraction	TAS
muscle organ development	NAS
myoblast fusion	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process [inference]

aldosterone biosynthetic process

glucocorticoid biosynthetic process [inference]

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process [inference]

aldosterone biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

olefinic compound biosynthetic process [inference]

ketone metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cortisol metabolic process [inference]

cortisol biosynthetic process

ketone biosynthetic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process [inference]

aldosterone biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process [inference]

aldosterone biosynthetic process

glucocorticoid biosynthetic process [inference]

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

glucocorticoid metabolic process [inference]

glucocorticoid biosynthetic process [inference]

cortisol biosynthetic process

cortisol metabolic process [inference]

cortisol biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process [inference]

aldosterone biosynthetic process

glucocorticoid biosynthetic process [inference]

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

primary alcohol biosynthetic process [inference]

cortisol metabolic process [inference]

cortisol biosynthetic process

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process [inference]

cortisol biosynthetic process

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

olefinic compound metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cortisol metabolic process [inference]

cortisol biosynthetic process

olefinic compound biosynthetic process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus

cellular response to metal ion [inference]

cellular response to potassium ion

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

cell-cell fusion [inference]

syncytium formation by cell-cell fusion [inference]

myoblast fusion

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

muscle organ development

muscle structure development [inference]

muscle organ development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to metal ion [inference]

response to potassium ion [inference]

cellular response to potassium ion

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus

cellular response to metal ion [inference]

cellular response to potassium ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion import

calcium ion import across plasma membrane

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

calcium ion import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction

regulation of reproductive process [inference]

regulation of acrosome reaction [inference]

positive regulation of acrosome reaction

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process [inference]

aldosterone biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

regulation of membrane potential

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	EXP
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IEA
voltage-gated calcium channel complex	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated calcium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

cellular anatomical structure [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
ion channel activity	IEA
monoatomic ion channel activity	IEA
voltage-gated monoatomic ion channel activity	IDA
voltage-gated calcium channel activity	IDA
voltage-gated calcium channel activity	IMP

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation channel activity

calcium channel activity [inference]

voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

calcium channel activity [inference]

voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation channel activity

calcium channel activity [inference]

voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

binding [inference]

protein binding

scaffold protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

voltage-dependent t-type calcium channel subunit alpha

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
calcium ion import
calcium ion transmembrane transport
low voltage-gated calcium channel activity
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
positive regulation of calcium ion-dependent exocytosis
voltage-gated sodium channel activity

Displaying **all 4** entries
InterPro
Ion transport domain
Voltage-dependent calcium channel, T-type, alpha-1 subunit
Voltage-dependent channel domain superfamily
Voltage-gated cation channel calcium and sodium

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1825	childhood absence epilepsy	Alliance of Genome Resources
DOID:446	primary hyperaldosteronism	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	114862	RGD:68943
Danio rerio	560875	ZFIN:ZDB-GENE-130103-1

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements