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cholinergic receptor nicotinic alpha 6 subunit

Summary

Gene Symbol

CHRNA6

Organism

Homo sapiens (human)

External Links

NCBI Gene

8973

KEGG Gene ID

PubChem

8973

Alliance of Genome Resources

HGNC:15963

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15825

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 25 in total

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GO Term	Evidence Code	PMID
synaptic transmission, cholinergic	IBA
neuromuscular synaptic transmission	IBA
regulation of dopamine secretion	ISS
ion transmembrane transport	IBA
monoatomic ion transmembrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction

cell surface receptor signaling pathway [inference]

chemical synaptic transmission, postsynaptic

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

chemical synaptic transmission, postsynaptic

behavior [inference]

adult behavior [inference]

behavioral response to nicotine

response to stimulus [inference]

response to chemical [inference]

response to nicotine

response to nitrogen compound [inference]

response to acetylcholine

response to oxygen-containing compound [inference]

response to acetylcholine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

chemical synaptic transmission, postsynaptic

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

presynaptic modulation of chemical synaptic transmission

regulation of secretion by cell [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of biological quality [inference]

regulation of membrane potential [inference]

membrane depolarization

regulation of postsynaptic membrane potential

excitatory postsynaptic potential

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
acetylcholine-gated channel complex	TAS
acetylcholine-gated channel complex	IDA
acetylcholine-gated channel complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

synapse

dopaminergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
monoatomic ion channel activity	IEA
ion channel activity	IEA
extracellular ligand-gated monoatomic ion channel activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

ligand-gated monoatomic cation channel activity [inference]

acetylcholine-gated monoatomic cation-selective channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

acetylcholine receptor activity

neurotransmitter receptor activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [inference]

acetylcholine-gated monoatomic cation-selective channel activity

postsynaptic neurotransmitter receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:809	cocaine abuse	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:0050742	nicotine dependence	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 12 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	172150	WB:WBGene00006797
Mus musculus	11440	MGI:106213
Caenorhabditis elegans	172105	WB:WBGene00006774
Caenorhabditis elegans	172703	WB:WBGene00006765
Caenorhabditis elegans	178269	WB:WBGene00002974
Caenorhabditis elegans	180936	WB:WBGene00000042
Caenorhabditis elegans	180937	WB:WBGene00000043
Drosophila melanogaster	38545	FB:FBgn0000038
Drosophila melanogaster	42918	FB:FBgn0000036
Drosophila melanogaster	42919	FB:FBgn0000039