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Guidelines

MIRAGE

NIMA related kinase 9

Summary

Gene Symbol

NEK9

Organism

Homo sapiens (human)

External Links

NCBI Gene

91754

PubChem

91754

Alliance of Genome Resources

HGNC:18591

JoGo

NEK9

TogoVar

NEK9

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Magnesium
Metal-binding
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Serine/threonine-protein kinase

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A7I2V5R1	Nercc1 kinase Never in mitosis A-related kinase 9
Q8TD19	Nercc1 kinase Never in mitosis A-related kinase 9 NimA-related kinase 8
A0A7I2V454	Nercc1 kinase Never in mitosis A-related kinase 9
Q6PKF2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitotic cell cycle	IDA
mitotic cell cycle	IBA
regulation of mitotic cell cycle	IDA
cell division

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle

cell division

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell cycle [inference]

regulation of mitotic cell cycle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	EXP
nucleus	IEA
cytoplasm	IEA
centrosome	IDA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

microtubule organizing center [inference]

centrosome

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein kinase activity	IEA
protein serine/threonine kinase activity	IDA
protein serine/threonine kinase activity	IBA
protein serine/threonine kinase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Serine/threonine-protein kinase Nek9

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
kinase activity
metal ion binding
nucleotide binding
phosphorylation
protein kinase binding

Displaying **all 2** entries
InterPro
Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Regulator of chromosome condensation, RCC1

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060558	lethal congenital contracture syndrome	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026