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leucine rich glioma inactivated 1

Summary

Gene Symbol

LGI1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9211

KEGG Gene ID

PubChem

9211

Alliance of Genome Resources

HGNC:6572

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Disease variant
Endoplasmic reticulum
Epilepsy
Glycoprotein
Golgi apparatus
Leucine-rich repeat
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Synapse

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A0S2Z4S7
A0A0S2Z5G1
A0A0S2Z4X3
O95970	Epitempin-1
A0A1B0GUD3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

1

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GO Term	Evidence Code	PMID
signal transduction	IEA
nervous system development	TAS
axon guidance	IMP
positive regulation of cell growth	IMP
neuron projection development	IMP

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to membrane [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein-containing complex localization [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

receptor localization to synapse [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

positive regulation of signaling [inference]

positive regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

positive regulation of synaptic transmission

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of AMPA receptor activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission

positive regulation of cell growth

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of potassium ion transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

positive regulation of cell communication [inference]

positive regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

positive regulation of synaptic transmission

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of AMPA receptor activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission

positive regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of potassium ion transmembrane transport [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

regulation of synapse organization [inference]

regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of AMPA receptor activity

regulation of transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

regulation of AMPA receptor activity

negative regulation of molecular function [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of potassium ion transmembrane transporter activity [inference]

negative regulation of voltage-gated potassium channel activity

Displaying entries **1 - 5** of 17 in total

1

2

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Next ›

Last »
GO Term	Evidence Code	PMID
extracellular region	EXP
extracellular region	TAS
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell junction [inference]

synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
signaling receptor binding	IPI
protein binding	IPI
receptor ligand activity	ISS
receptor ligand activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060748	familial temporal lobe epilepsy 1	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	56839	MGI:1861691
Rattus norvegicus	252892	RGD:628742

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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Acknowledgements