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MIRAGE

phosphatidylinositol glycan anchor biosynthesis class M

Summary

Gene Symbol

PIGM

Aliases

DPM:GlcN-(acyl-)PI mannosyltransferase
GPI mannosyltransferase 1
GPI-MT-I
PIG-M
dol-P-Man dependent GPI mannosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

93183

GGDB ID

gg221

HGNC

18858

mRNA

NM_145167

map

1q23.2

Protein

NP_660150

OMIM

610273

KEGG Gene ID

hsa:93183

PubChem

93183

Alliance of Genome Resources

HGNC:18858

JoGo

PIGM

TogoVar

PIGM

Annotation

Keyword

Endoplasmic reticulum
GPI-anchor biosynthesis
Glycosyltransferase
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H3S5	GPI mannosyltransferase I Phosphatidylinositol-glycan biosynthesis class M protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
GPI anchor biosynthetic process	IDA
GPI anchor biosynthetic process	IBA
GPI anchor biosynthetic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	NAS
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA
endoplasmic reticulum membrane	IEA
membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

glycosylphosphatidylinositol-mannosyltransferase I complex

intracellular protein-containing complex [inference]

mannosyltransferase complex [inference]

glycosylphosphatidylinositol-mannosyltransferase I complex

catalytic complex [inference]

transferase complex [inference]

mannosyltransferase complex [inference]

glycosylphosphatidylinositol-mannosyltransferase I complex

cellular anatomical structure [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
mannosyltransferase activity	IBA
GPI mannosyltransferase activity	IEA
protein binding	IPI
alpha-1,4-mannosyltransferase activity	IEA
dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity

GPI mannosyltransferase activity

dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity

alpha-1,4-mannosyltransferase activity

dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg221

Gene Symbol

PIGM

KEGG BRITE Database

Orthology

K05284

Name

GPI mannosyltransferase 1 subunit M [EC:2.4.1.-]

References

11226175

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05919	2.4.1.-	G74840NI G94923PG	G60131QC

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of 11 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000750	Delayed speech and language development
HP:0001409	Portal hypertension
HP:0001744	Splenomegaly
HP:0002121	Generalized non-motor (absence) seizure
HP:0002240	Hepatomegaly
HP:0003593	Infantile onset
HP:0004936	Venous thrombosis
HP:0005561	Abnormal bone marrow cell morphology
HP:0010819	Atonic seizure

Displaying 1 entry
Disease ID	Disease Name
OMIM:610293	hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency

PubChem Disease

MedGen Diseases

Hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency

OMIM Phenotypes

GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 1; GPIBD1

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006247
Gene Name: phosphatidylinositol glycan anchor biosynthesis, class M

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	67556	MGI:1914806
Rattus norvegicus	79112	RGD:71041
Caenorhabditis elegans	174736	WB:WBGene00007189
Drosophila melanogaster	37470	FB:FBgn0034649
Saccharomyces cerevisiae S288C	853470	SGD:S000003774
Danio rerio	393361	ZFIN:ZDB-GENE-040426-1393
Xenopus laevis	108719045	Xenbase:XB-GENE-17334883
Xenopus tropicalis	493482	Xenbase:XB-GENE-5730241

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026