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beta-1,4-galactosyltransferase 6

Summary

Gene Symbol

B4GALT6

Aliases

UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase
beta4GalT-VI

Organism

Homo sapiens (human)

External Links

NCBI Gene

9331

GGDB ID

gg082

HGNC

929

mRNA

NM_004775

map

18q11

Protein

NP_004766

OMIM

604017

KEGG Gene ID

hsa:9331

PubChem

9331

Alliance of Genome Resources

HGNC:929

JoGo

B4GALT6

TogoVar

B4GALT6

Annotation

Keyword

Alternative splicing
Calcium
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid biosynthesis
Magnesium
Manganese
Metal-binding
Proteomics identification
Reference proteome
Signal-anchor
Sphingolipid metabolism
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q59GB5
Q8WZ95
G3XA83
Q9UBX8	Glucosylceramide beta-1,4-galactosyltransferase Lactosylceramide synthase UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6 UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
lactosylceramide biosynthetic process	IDA
ganglioside biosynthetic process	ISS
ganglioside biosynthetic process	IEA
carbohydrate metabolic process	IEA
sphingolipid metabolic process

GO Hierarchy

biological process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

axon ensheathment in central nervous system [inference]

central nervous system myelination

myelination [inference]

central nervous system myelination

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

ceramide biosynthetic process [inference]

carbohydrate derivative biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

ceramide biosynthetic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

ceramide biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

ceramide biosynthetic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside biosynthetic process

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular developmental process [inference]

cell maturation [inference]

neuron maturation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation

cellular developmental process [inference]

cell maturation [inference]

neuron maturation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IEA
Golgi apparatus	IBA
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity	IMP
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity	IBA
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity	IEA
glycosyltransferase activity	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity

UDP-galactosyltransferase activity [inference]

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Beta-1,4-galactosyltransferase 4

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
galactosyltransferase activity
glycosylation
metal ion binding
transferase activity

Displaying **all 4** entries
InterPro
Beta-1,4-galactosyltransferase
Galactosyltransferase, C-terminal
Galactosyltransferase, N-terminal
Nucleotide-diphospho-sugar transferases

Human Protein Atlas

ENSG00000118276

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg082

Gene Symbol

B4GALT6

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G71142DF	Cer	G84224TW	Cer	9593693

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G71142DF	Cer	G84224TW	Cer	9593693
UDP-Gal	G71142DF		G84224TW		10580128

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_062711	NM_019737
Rattus norvegicus	NP_113928	NM_031740

KEGG BRITE Database

Orthology

K07553

Name

beta-1,4-galactosyltransferase 6 [EC:2.4.1.274]

References

10320813

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06276	2.4.1.274	G71142DF	G84224TW

Rhea

RHEA:31495

a β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine + UDP-α-D-galactose

H⁺ + a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + UDP

Enzyme

2.4.1.274

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000039
Gene Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	56386	MGI:1928380
Rattus norvegicus	65196	RGD:71046
Drosophila melanogaster	43425	FB:FBgn0039625
Danio rerio	393912	ZFIN:ZDB-GENE-040426-789
Xenopus laevis	779435	Xenbase:XB-GENE-984619
Xenopus laevis	108695277	Xenbase:XB-GENE-17343520
Xenopus tropicalis	548965	Xenbase:XB-GENE-984613

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements