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klotho

Summary

Gene Symbol

Aliases

KLA
alpha-klotho

Organism

Homo sapiens (human)

External Links

NCBI Gene

9365

HGNC

6344

KEGG Gene ID

hsa:9365

PubChem

9365

Alliance of Genome Resources

HGNC:6344

JoGo

TogoVar

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Glycoprotein
Glycosidase
Hormone
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Vitamin D

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UEF7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
negative regulation of systemic arterial blood pressure	IEA
carbohydrate metabolic process	IEA
energy reserve metabolic process
determination of adult lifespan
fibroblast growth factor receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process

biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

multicellular organismal process [inference]

determination of adult lifespan

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

response to growth factor [inference]

response to fibroblast growth factor

response to activity

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

response to lipid [inference]

response to vitamin D

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to angiotensin

response to oxygen-containing compound [inference]

response to vitamin D

response to peptide hormone [inference]

response to angiotensin

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of biological quality [inference]

regulation of blood pressure [inference]

negative regulation of blood pressure [inference]

negative regulation of systemic arterial blood pressure

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	EXP
extracellular region	TAS
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
beta-glucuronidase activity	ISS
beta-glucuronidase activity	IEA
fibroblast growth factor receptor binding	IBA
fibroblast growth factor receptor binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

glucosidase activity [inference]

beta-glucosidase activity

glucuronidase activity [inference]

beta-glucuronidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

growth factor receptor binding [inference]

fibroblast growth factor receptor binding

growth factor binding [inference]

fibroblast growth factor binding

lipid binding [inference]

steroid binding [inference]

vitamin D binding

small molecule binding [inference]

vitamin binding [inference]

vitamin D binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K14756

Name

klotho [EC:3.2.1.31]

References

Rhea

RHEA:17633

H₂O + a β-D-glucuronoside

an alcohol + D-glucuronate

Enzyme

3.2.1.31

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:4372	intracranial embolism	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:2247	spondylosis	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 14 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000103	Polyuria
HP:0000787	Nephrolithiasis
HP:0000938	Osteopenia
HP:0001959	Polydipsia
HP:0002315	Headache
HP:0002514	Cerebral calcification
HP:0002905	Hyperphosphatemia
HP:0003072	Hypercalcemia
HP:0003165	Elevated circulating parathyroid hormone level