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acid phosphatase 4

Summary

Gene Symbol

ACP4

Aliases

testicular acid phosphatase

Organism

Homo sapiens (human)

External Links

NCBI Gene

93650

HGNC

14376

KEGG Gene ID

[""]

PubChem

93650

Alliance of Genome Resources

HGNC:14376

Annotation

Keyword

Alternative splicing
Amelogenesis imperfecta
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BZG2	Acid phosphatase 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
negative regulation of protein processing	IMP
negative regulation of neuron projection development	IDA
odontogenesis	IMP
regulation of neuronal synaptic plasticity	IDA
regulation of neuronal synaptic plasticity	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation [inference]

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

regulation of ERBB signaling pathway [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

regulation of ERBB signaling pathway [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

regulation of ERBB signaling pathway [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of ERBB4 signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
lysosome	IBA
membrane	IEA
postsynaptic membrane
glutamatergic synapse	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
acid phosphatase activity	IBA
acid phosphatase activity	IEA
protein tyrosine phosphatase activity	IDA
protein tyrosine phosphatase activity	IBA
protein tyrosine phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

acid phosphatase activity

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor tyrosine kinase binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
acid phosphatase activity
dephosphorylation
lysosome organization

Displaying **all 3** entries
InterPro
Histidine acid phosphatase active site
Histidine phosphatase superfamily, clade-2
Histidine phosphatase superfamily

Rhea

RHEA:15017

H₂O + a phosphate monoester

an alcohol + phosphate

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080953	amelogenesis imperfecta type 1J	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 7** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000670	Carious teeth
HP:0000687	Widely spaced teeth
HP:0000705	Amelogenesis imperfecta
HP:0006297	Enamel hypoplasia
HP:0010299	Abnormal dentin morphology
HP:0011094	Increased overbite