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palmitoyl-protein thioesterase 2

Summary

Gene Symbol

PPT2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9374

HGNC

9326

KEGG Gene ID

hsa:9374

PubChem

9374

Alliance of Genome Resources

HGNC:9326

JoGo

PPT2

TogoVar

PPT2

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UMR5	Palmitoyl-protein thioesterase 2 S-thioesterase G14
A0A1U9X8D2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
fatty-acyl-CoA biosynthetic process	TAS
macromolecule depalmitoylation	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

macromolecule metabolic process [inference]

macromolecule modification [inference]

macromolecule deacylation [inference]

macromolecule depalmitoylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

fatty acid derivative metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process

fatty acid derivative biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

fatty-acyl-CoA metabolic process [inference]

fatty-acyl-CoA biosynthetic process

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

fatty-acyl-CoA biosynthetic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	IBA
lysosome	NAS
lysosome	IBA
lysosome	IEA
lysosomal lumen	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
palmitoyl hydrolase activity	IDA
palmitoyl hydrolase activity	IBA
palmitoyl hydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity

palmitoyl hydrolase activity

deacylase activity [inference]

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012349
Gene Name: palmitoyl-protein thioesterase 2

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	54397	MGI:1860075
Drosophila melanogaster	34564	FB:FBgn0032358
Xenopus laevis	379689	Xenbase:XB-GENE-865230
Rattus norvegicus	54398	RGD:620375

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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