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eukaryotic translation initiation factor 2 alpha kinase 3

Summary

Gene Symbol

EIF2AK3

Organism

Homo sapiens (human)

External Links

NCBI Gene

9451

KEGG Gene ID

PubChem

9451

Alliance of Genome Resources

HGNC:3255

Annotation

Keyword

3D-structure
ADP-ribosylation
ATP-binding
Diabetes mellitus
Disease variant
Endoplasmic reticulum
Glycoprotein
Initiation factor
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase
Signal
Stress response
Translation regulation
Transmembrane helix
Tyrosine-protein kinase
Unfolded protein response

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A804HIT4	PRKR-like endoplasmic reticulum kinase Pancreatic eIF2-alpha kinase Protein tyrosine kinase EIF2AK3
Q9NZJ5	PRKR-like endoplasmic reticulum kinase Pancreatic eIF2-alpha kinase Protein tyrosine kinase EIF2AK3
B3KY45	PRKR-like endoplasmic reticulum kinase Pancreatic eIF2-alpha kinase Protein tyrosine kinase EIF2AK3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
skeletal system development	ISS
ossification	IMP
angiogenesis	IMP
chondrocyte development	ISS
regulation of translational initiation	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

intracellular signaling cassette [inference]

calcium-mediated signaling

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

cellular developmental process [inference]

cell development [inference]

chondrocyte development

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress

ER overload response

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to cold

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to biotic stimulus [inference]

ER overload response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

endocrine pancreas development

cell development [inference]

chondrocyte development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell development [inference]

chondrocyte development

response to stimulus [inference]

response to stress [inference]

response to cold [inference]

cellular response to cold

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress

ER overload response

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to cold

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

response to topologically incorrect protein [inference]

response to unfolded protein

response to starvation [inference]

cellular response to starvation [inference]

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to biotic stimulus [inference]

cellular response to biotic stimulus [inference]

ER overload response

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold [inference]

cellular response to cold

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

response to starvation [inference]

cellular response to starvation [inference]

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to chemical [inference]

response to metal ion [inference]

response to manganese ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress

ER overload response

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to cold

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to biotic stimulus [inference]

ER overload response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of myelination

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

intracellular signaling cassette [inference]

calcium-mediated signaling

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of myelination [inference]

negative regulation of myelination

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of myelination

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

Displaying entries **6 - 10** of 15 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IC
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	NAS
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

organelle membrane contact site [inference]

mitochondria-associated endoplasmic reticulum membrane contact site

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
translation initiation factor activity
protein kinase activity	TAS
protein kinase activity	IDA
protein kinase activity	IEA
protein serine/threonine kinase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein serine kinase activity

binding [inference]

protein binding

enzyme binding

phosphatase binding [inference]

protein phosphatase binding

heat shock protein binding [inference]

Hsp90 protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

translation regulator activity

translation factor activity [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

eukaryotic translation initiation factor 2 alpha kinase 3

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
cellular response to chemical stimulus
eukaryotic translation initiation factor 2alpha kinase activity
kinase activity
nucleotide binding
phosphorylation
response to endoplasmic reticulum stress
response to unfolded protein

Displaying **all 6** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Quinoprotein alcohol dehydrogenase-like superfamily
Serine/threonine-protein kinase, active site
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:0090060	Wolcott-Rallison syndrome	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13666	MGI:1341830
Rattus norvegicus	29702	RGD:70884
Caenorhabditis elegans	181334	WB:WBGene00003970
Drosophila melanogaster	40653	FB:FBgn0037327

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements