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carbohydrate sulfotransferase 3

Summary

Gene Symbol

CHST3

Aliases

C6ST
C6ST1
chondroitin 6 sulfotransferase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9469

GGDB ID

gg025

HGNC

1971

mRNA

NM_004273

map

10q22.1

Protein

NP_004264

OMIM

603799

KEGG Gene ID

hsa:9469

PubChem

9469

Alliance of Genome Resources

HGNC:1971

Annotation

Keyword

Carbohydrate metabolism
Disease variant
Glycoprotein
Golgi apparatus
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7LGC8	Chondroitin 6-O-sulfotransferase 1 Chondroitin 6-sulfotransferase Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
N-acetylglucosamine metabolic process	IBA
sulfur compound metabolic process	IDA	9883891
chondroitin sulfate biosynthetic process	TAS
chondroitin sulfate biosynthetic process	IDA	9883891

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

T cell homeostasis

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

amino sugar metabolic process [inference]

glucosamine-containing compound metabolic process [inference]

N-acetylglucosamine metabolic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

T cell homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

T cell homeostasis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
trans-Golgi network

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

Displaying **all 5** entries
GO Term	Evidence Code	PMID
N-acetylglucosamine 6-O-sulfotransferase activity	IBA
chondroitin 6-sulfotransferase activity	TAS
chondroitin 6-sulfotransferase activity	IDA	15215498 9883891
chondroitin 6-sulfotransferase activity	IBA
proteoglycan sulfotransferase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity [inference]

N-acetylglucosamine 6-O-sulfotransferase activity

chondroitin sulfotransferase activity [inference]

chondroitin 6-sulfotransferase activity

proteoglycan sulfotransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sulfotransferase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
N-acetylglucosamine 6-O-sulfotransferase activity
N-acetylglucosamine metabolic process
sulfotransferase activity
transferase activity

Displaying **all 2** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Sulfotransferase domain

Human Protein Atlas

ENSG00000122863

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg025

Gene Symbol

CHST3

Reactions

Displaying **all 3** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
PAPS	G73480MV		10781596
PAPS	G00054MO		9147050
PAPS	G49108TO	-O-CH3	10781596

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_058083	NM_016803
Rattus norvegicus	NP_445860	NM_053408

Rhea

RHEA:11108

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

2.8.2.17

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050813	spondyloepiphyseal dysplasia with congenital joint dislocations	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:2256	osteochondrodysplasia	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **31 - 40** of **145** in total

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HPO ID	HPO Term
HP:0000878	11 pairs of ribs
HP:0000914	Shield chest
HP:0000926	Platyspondyly
HP:0000938	Osteopenia
HP:0000939	Osteoporosis
HP:0000973	Cutis laxa
HP:0000974	Hyperextensible skin
HP:0001087	Developmental glaucoma
HP:0001090	Abnormally large globe
HP:0001156	Brachydactyly

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:245600	Larsen-like syndrome, B3GAT3 type
ORPHA:263463	spondyloepiphyseal dysplasia with congenital joint dislocations
OMIM:143095	spondyloepiphyseal dysplasia with congenital joint dislocations

PubChem Disease

GHR Health Conditions

CHST3-related skeletal dysplasia

MedGen Diseases

OMIM Phenotypes

SPONDYLOEPIPHYSEAL DYSPLASIA WITH CONGENITAL JOINT DISLOCATIONS; SEDCJD

KEGG Diseases

Spondyloepiphyseal dysplasia with congenital joint dislocations

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of **111** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	4166	FB:FBgn0031826
Drosophila melanogaster	8534	FB:FBgn0031826
Drosophila melanogaster	9435	FB:FBgn0031826
Xenopus tropicalis	9469	Xenbase:XB-GENE-993289
Drosophila melanogaster	23563	FB:FBgn0031826
Drosophila melanogaster	26887	FB:FBgn0031826
Danio rerio	33913	ZFIN:ZDB-GENE-090312-180
Xenopus tropicalis	33914	Xenbase:XB-GENE-993289
Mus musculus	53374	Xenbase:XB-GENE-993289	MOUSE01384
Drosophila melanogaster	54371	FB:FBgn0031826

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

PubChem Disease

International Collaboration

Acknowledgements