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scavenger receptor class B member 2

Summary

Gene Symbol

SCARB2

Organism

Homo sapiens (human)

External Links

NCBI Gene

950

KEGG Gene ID

PubChem

950

Alliance of Genome Resources

HGNC:1665

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Lysosome
Neurodegeneration
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A1W2PRF6
Q14108	85 kDa lysosomal membrane sialoglycoprotein CD36 antigen-like 2 Lysosome membrane protein II Scavenger receptor class B member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
protein targeting to lysosome	NAS
protein targeting to lysosome	IMP
protein targeting to lysosome	IBA
protein targeting to lysosome	IEA
receptor-mediated endocytosis	ISS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

autophagy

lipid catabolic process [inference]

glycolipid catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

glycolipid catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid catabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid catabolic process

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

endosome to plasma membrane protein transport

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

process utilizing autophagic mechanism [inference]

autophagy

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

endosome to plasma membrane protein transport

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to lysosome [inference]

protein targeting to lysosome

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of localization [inference]

transport [inference]

lipid transport [inference]

phospholipid transport [inference]

aminophospholipid transport

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

endosome to plasma membrane protein transport

organophosphate ester transport [inference]

phospholipid transport [inference]

aminophospholipid transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

endosome to plasma membrane protein transport

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

nitrogen compound transport [inference]

aminophospholipid transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

endosome to plasma membrane protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

endosome to plasma membrane protein transport

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

endosome to plasma membrane protein transport

vacuolar transport [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of carbohydrate catabolic process

regulation of lipid catabolic process [inference]

regulation of glucosylceramide catabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate catabolic process

regulation of lipid metabolic process [inference]

regulation of lipid catabolic process [inference]

regulation of glucosylceramide catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

regulation of organelle organization [inference]

regulation of vacuole organization [inference]

regulation of lysosome organization

regulation of endosome organization

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
lysosome	IEA
lysosomal membrane	ISS
lysosomal membrane	TAS
lysosomal membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

late endosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
virus receptor activity
phosphatidylserine binding	ISS
phosphatidylserine binding	IEA
transmembrane signaling receptor activity	TAS
scavenger receptor activity	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

protein-folding chaperone binding

exogenous protein binding [inference]

virus receptor activity

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

phospholipid binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylserine binding

cation binding [inference]

phosphatidylcholine binding

alcohol binding [inference]

cholesterol binding

quaternary ammonium group binding [inference]

phosphatidylcholine binding

modified amino acid binding [inference]

phosphatidylserine binding

cargo receptor activity

scavenger receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Scavenger receptor class B member

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
scavenger receptor activity

Displaying 1 entry
InterPro
CD36 family

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111444	progressive myoclonus epilepsy 4	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	12492	MGI:1196458
Rattus norvegicus	117106	RGD:621882
Caenorhabditis elegans	176787	WB:WBGene00013578
Caenorhabditis elegans	176673	WB:WBGene00013039