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MIRAGE

hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase

Summary

Gene Symbol

H6PD

Aliases

6-phosphogluconolactonase
GDH/6PGL endoplasmic bifunctional protein
H6PDH

Organism

Homo sapiens (human)

External Links

NCBI Gene

9563

HGNC

4795

KEGG Gene ID

hsa:9563

PubChem

9563

Alliance of Genome Resources

HGNC:4795

JoGo

H6PD

TogoVar

H6PD

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Endoplasmic reticulum
Glucose metabolism
Glycoprotein
Hydrolase
Multifunctional enzyme
NAD
NADP
Oxidoreductase
Proteomics identification
Pyrrolidone carboxylic acid
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O95479

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
glucose metabolic process	IBA
glucose metabolic process	IEA
pentose-phosphate shunt	IEA
NADP+ metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

NADPH regeneration [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADPH regeneration [inference]

carbohydrate derivative metabolic process [inference]

pentose-phosphate shunt, oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

response to stimulus [inference]

response to nutrient levels

response to chemical [inference]

response to oxygen-containing compound [inference]

response to alcohol

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone metabolic process [inference]

regulation of glucocorticoid metabolic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of glucocorticoid metabolic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of steroid biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

regulation of glucocorticoid metabolic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
endoplasmic reticulum	IEA
endoplasmic reticulum lumen	IDA
endoplasmic reticulum lumen	IEA
sarcoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
6-phosphogluconolactonase activity	IEA
carbohydrate binding	IEA
glucose 1-dehydrogenase (NAD+) activity	ISS
glucose 1-dehydrogenase (NAD+) activity	IEA
glucose 1-dehydrogenase (NADP+) activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors

glucose dehydrogenase activity [inference]

glucose 1-dehydrogenase [NAD(P)+] activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

glucose-6-phosphate dehydrogenase activity

glucose 1-dehydrogenase [NAD(P)+] activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

6-phosphogluconolactonase activity

binding [inference]

carbohydrate binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glucose-6-phosphate

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
NADP binding
glucose metabolic process
glucose-6-phosphate dehydrogenase activity
oxidoreductase activity, acting on CH-OH group of donors
pentose-phosphate shunt, oxidative branch

Displaying **all 4** entries
InterPro
Glucose-6-phosphate dehydrogenase, C-terminal
Glucose-6-phosphate dehydrogenase, NAD-binding
Glucose-6-phosphate dehydrogenase
NAD(P)-binding domain superfamily

Human Protein Atlas

ENSG00000049239

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K13937

Name

hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]

References

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0090141	cortisone reductase deficiency 1	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:0090139	cortisone reductase deficiency	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 11 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000789	Infertility
HP:0000826	Precocious puberty
HP:0000876	Oligomenorrhea
HP:0001007	Hirsutism
HP:0001061	Acne
HP:0001513	Obesity
HP:0001596	Alopecia
HP:0003581	Adult onset
HP:0003596	Middle age onset

Displaying 1 entry
Disease ID	Disease Name
OMIM:604931	cortisone reductase deficiency 1

PubChem Disease

MedGen Diseases

Cortisone reductase deficiency 1

OMIM Phenotypes

CORTISONE REDUCTASE DEFICIENCY 1; CORTRD1

KEGG Diseases

Cortisone reductase deficiency

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	100198	MGI:2140356

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026