G49108TO
| Organisms | Evidence | 
|---|---|
| Mus musculus (house mouse) | |
| Rattus norvegicus (Norway rat) | |
| Homo sapiens (human) | |
| Drosophila melanogaster (fruit fly) | |
| Streptococcus pneumoniae | 
| Gene Symbol | Donor | Acceptor | Reducing terminal(Acceptor) | Product | Reducing terminal(Product) | Reference | 
|---|---|---|---|---|---|---|
| B3GALT1 | UDP-Gal | 
                          
                             | 
                    Lemieux | 
                          
                             | 
                    Lemieux | |
| B4GALNT3 | UDP-GalNAc | 
                          
                             | 
                    R | 
                          
                             | 
                    R | |
| B3GALNT2 | UDP-GalNAc | 
                          
                             | 
                    R | 
                          
                             | 
                    R | |
| B4GALNT4 | UDP-GalNAc | 
                          
                             | 
                    R | 
                          
                             | 
                    R | |
| B4GALT1 | UDP-Glc | 
                          
                             | 
                    R | 
                          
                             | 
                    R | 
| Gene Symbol | Donor | Acceptor | Reducing terminal(Acceptor) | Product | Reducing terminal(Product) | Reference | 
|---|---|---|---|---|---|---|
| B4GALT5 | (not applicable) | 
                          
                             | 
                    [beta]-S-pNP | 
                          
                             | 
                    [beta]-S-pNP | |
| B4GALT3 | UDP-Gal | 
                          
                             | 
                    Benzyl-[beta] | 
                          
                             | 
                    Benzyl-[beta] | |
| B4GALT4 | UDP-Gal | 
                          
                             | 
                    [beta]-1-Benzl | 
                          
                             | 
                    [beta]-1-Benzl | |
| B3GALT2 | UDP-Gal | 
                          
                             | 
                    Lemieux | 
                          
                             | 
                    Lemieux | |
| B4GALT4 | UDP-Gal | 
                          
                             | 
                    [beta]-1-4-methyl-umbelliferyl | 
                          
                             | 
                    [beta]-1-4-methyl-umbelliferyl | 
| Pathway Name | Organism | 
|---|---|
| Antimicrobial peptides | Xenopus tropicalis | 
| Antimicrobial peptides | Rattus norvegicus | 
| Antimicrobial peptides | Danio rerio | 
| Antimicrobial peptides | Bos taurus | 
| Antimicrobial peptides | Canis familiaris | 
| Antimicrobial peptides | Sus scrofa | 
| Antimicrobial peptides | Dictyostelium discoideum | 
| Antimicrobial peptides | Mus musculus | 
| Antimicrobial peptides | Drosophila melanogaster | 
| Antimicrobial peptides | Homo sapiens | 
RES 1b:b-dglc-HEX-1:5 2s:n-acetyl LIN 1:1d(2+1)2n
| PubMed ID | Title | First Author | Publication Date | Source | 
|---|---|---|---|---|
| 37782796 | Dual-pocket inhibition of Navchannels by the antiepileptic drug lamotrigine | Huang J | 2023 Oct 02 | 
                  
  | 
          
| 37507081 | Differential Detection of O-GlcNAcylated proteins in the heart using antibodies | Narayanan B | 2023 Oct 01 | 
                  
  | 
          
| 37539459 | Best practices in assessing cardiac protein O-GlcNAcylation by immunoblot | Zou L | 2023 Oct 01 | 
                  
  | 
          
| 37660465 | Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor | Imai Y | 2023 Oct 01 | 
                  
  | 
          
| 37597690 | Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies | Irobalieva RN | 2023 Oct 01 | 
                  
  | 
          
| 37602414 | Hexosamine biosynthetic pathway and O-GlcNAc cycling of glucose metabolism in brain function and disease | Kim DY | 2023 Oct 01 | 
                  
  | 
          
| 37482134 | An unusual conformation from Na+-sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na+-binding | Abe K | 2023 Oct | 
                  
  | 
          
| 37842796 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS‐CoV‐2 | Ahn H | 2023 Oct | 
                  
  | 
          
| 37660581 | A molting chemical cue (N-acetylglucosamine-6-phosphate) contributes to cannibalism of Chinese mitten crab Eriocheir sinensis | Zi X | 2023 Oct | 
                  
  | 
          
| 37633052 | N-Acetylglucosamine mitigates lung injury and pulmonary fibrosis induced by bleomycin | Li J | 2023 Oct | 
                  
  | 
          
| Title | Authors | Source | Publication Date | PubMed ID | 
|---|---|---|---|---|
| Dynamic glycosylation of the transcription factor CREB: a potential role in gene regulation. | 
                  
  | 
                    J Am Chem Soc | 2003 Jun 4 | 12769553 | 
| Effect of okadaic acid on O-linked N-acetylglucosamine levels in a neuroblastoma cell line. | 
                  
  | 
                    Biochim Biophys Acta | 1999 Oct 18 | 10572927 | 
| Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeats. | 
                  
  | 
                    J Biol Chem | 1999 Nov 5 | 10542233 | 
| An N-terminal region of Sp1 targets its proteasome-dependent degradation in vitro. | 
                  
  | 
                    J Biol Chem | 1999 May 21 | 10329728 | 
| Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine. | 
                  
  | 
                    J Biol Chem | 1992 Jan 5 | 1730617 | 
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Partly supported by NIH Common Fund Grant #1U01GM125267-01
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