GlyCosmos Portal

Amyloid-beta A4 protein

Summary

UniProt ID: A0A140VJC8
Gene Symbol: APP A4 AD1
Gene ID: 351
Organism: Homo sapiens (human)

External Links

GlycoProtDB: GPDB0008538
Re-Glyco: A0A140VJC8

Annotation

Keyword: Amyloid Apoptosis Cell adhesion Cell membrane Cell projection Coated pit Coiled coil Copper Cytoplasm Cytoplasmic vesicle Disulfide bond Endocytosis Endoplasmic reticulum Endosome Golgi apparatus Heparin-binding Iron Isopeptide bond Metal-binding Notch signaling pathway Nucleus Phosphoprotein Proteoglycan Secreted Serine protease inhibitor Signal Sulfation Transmembrane helix Ubl conjugation Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
calcium ion transport	IEA	GO_REF
endocytosis
cell adhesion
Notch signaling pathway
learning or memory	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

hippocampal neuron apoptotic process

vesicle-mediated transport [inference]

endocytosis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

locomotory behavior [inference]

swimming behavior

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to insulin-like growth factor stimulus

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus

response to chemical [inference]

response to hormone [inference]

response to insulin-like growth factor stimulus

response to metal ion [inference]

response to manganese ion [inference]

cellular response to manganese ion

response to lead ion

response to copper ion [inference]

cellular response to copper ion

cellular response to metal ion [inference]

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to peptide [inference]

response to cytokine [inference]

response to interleukin-1

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

response to alcohol [inference]

response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
obsolete extracellular space
nucleus	IEA	GO_REF
early endosome	IEA	GO_REF
endoplasmic reticulum	IEA	GO_REF
Golgi apparatus	IDA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium [inference]

growth cone lamellipodium

neuron projection [inference]

glial cell projection [inference]

astrocyte projection

actin-based cell projection [inference]

filopodium [inference]

growth cone filopodium

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Golgi-associated vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

platelet alpha granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Golgi-associated vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

platelet alpha granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Golgi-associated vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

platelet alpha granule

main axon

Displaying **all 5** entries
GO Term	Evidence Code	Reference
serine-type endopeptidase inhibitor activity	IEA	GO_REF GO_REF GO_REF
heparin binding	IEA	GO_REF GO_REF
peptidase activator activity	IEA	GO_REF
transition metal ion binding	IEA	GO_REF
growth factor receptor binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

growth factor receptor binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

enzyme activator activity [inference]

peptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
571				GlycoProtDB

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements