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SH3 and PX domain-containing protein 2B

Summary

UniProt ID: A1X283
Gene Symbol: FAD49 KIAA1295 SH3PXD2B TKS4
Gene ID: 285590
Organism: Homo sapiens (human)

External Links

GlyGen: A1X283
Re-Glyco: A1X283

Annotation

Keyword: Cell junction Cell projection Cytoplasm Differentiation Disease variant Phosphoprotein Proteomics identification Reference proteome Repeat SH3 domain

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
skeletal system development	IMP	PMID
skeletal system development	IEA	GO_REF
eye development	IMP	PMID
eye development	IEA	GO_REF GO_REF
superoxide metabolic process	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process

superoxide anion generation

cellular developmental process [inference]

cell differentiation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

membraneless organelle assembly [inference]

podosome assembly

cellular component disassembly [inference]

extracellular matrix disassembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

podosome assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

podosome assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

podosome assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

connective tissue development [inference]

adipose tissue development

animal organ development [inference]

sensory organ development [inference]

eye development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

Displaying **all 5** entries
GO Term	Evidence Code	Reference
podosome	ISS	GO_REF
podosome	IEA	GO_REF GO_REF
cytoplasm	ISS	GO_REF
cytoplasm	IBA	GO_REF
cytoplasm	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

podosome

intracellular organelle [inference]

intracellular membraneless organelle [inference]

podosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
phosphatidylinositol-5-phosphate binding	ISS	GO_REF
phosphatidylinositol-5-phosphate binding	IEA	GO_REF
superoxide-generating NADPH oxidase activator activity	IBA	GO_REF
phosphatidylinositol-3-phosphate binding	ISS	GO_REF
phosphatidylinositol-3-phosphate binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

SH2 domain binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol phosphate binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

superoxide-generating NADPH oxidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

superoxide-generating NADPH oxidase activator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites