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Leucine-rich repeat-containing G-protein coupled receptor 4

Summary

UniProt ID: B0BLW3
Gene Symbol: lgr4
Gene ID: 100144922
Organism: Xenopus tropicalis (tropical clawed frog)

External Links

Re-Glyco: B0BLW3

Annotation

Keyword: 3D-structure Biological rhythms Cell membrane Developmental protein Differentiation Disulfide bond G-protein coupled receptor Glycoprotein Leucine-rich repeat Reference proteome Repeat Signal Transmembrane helix Wnt signaling pathway

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
osteoblast differentiation	ISS	GO_REF
negative regulation of cytokine production	ISS	GO_REF
G protein-coupled receptor signaling pathway	IEA	GO_REF
spermatogenesis	ISS	GO_REF
Wnt signaling pathway

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

tissue remodeling [inference]

bone remodeling

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

rhythmic process

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production

Displaying **all 3** entries
GO Term	Evidence Code	Reference
plasma membrane	ISS	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	Reference
transmembrane signaling receptor activity	ISS	GO_REF
protein-hormone receptor activity	IEA	GO_REF
identical protein binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

identical protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGCPGWPLALFALLLASCSGGPSGVSSPAPCPAPCACDLDGGADCSGKGLVTVPDGLSVFTHSLDLSMNNITKLPEGAFKGFPYLEELRLAGNDLSIIHPMALSGLKELKVLTLQNNQLKTVPSESLKGLVSLQSLRLDANHIVTVPEDSFEGLVQLRHLWLDDNSLTEVPIRPLSNLPSLQALTLALNKISHIPDYAFSNLSSLVVLHLHNNKIRTLGPHCFHGLDNLEALDLNYNNLIDFPDSIRSLPNLKELGFHSNSITIIPDGAFVKNPLLRTIHLYDNPLSFVGNSAFQNLSDLHFLIIRGASNVQWFPNLTGTNNLESLTLTGTKIRSIPIKFCQEQKMLRTLDLSYNEISALVGFEGCSSLEEVYLQNNQIQEVQNETFQGLAALRMLDLSRNRIHTIHKEAFVTLKALTNLDLSFNDLTAFPTAGLHGLNQLKLTGNPNFKETLTAKDLIKLSSVSVPYAYQCCAFSACNSYMTTTVEEDRLRAQRLLLDHDRAAMDPDYMGTEDDKEHVQALIQCNPATGPFKPCEYLLGSWMIRLTVWFIFLLALIFNVIVIVTMFASCSQLTSSKLFIGLIAVSNLFMGVYTGTLTVLDTISWGQFAEFGIWWETGNGCKVAGFLAIFSSESAIFFLMLAAIERSLSAKDIIKKEKHQHLRKFQVASLLAVLLAAAAGCLPLFHIGEFSSSPLCLPFPTGETPSLGFTVTLVLLNSLAFLIMVITYTKLYCTIEKEDLSENAESSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAIYISPEIMKSVTLIFLPLPACLNPVLYVFFNPKFKEDWKLLRWRLTKRSGSVAVATNSQRGCVTQDFYYDFGMYSHLQGGNFAVCDYCESVLLKNPPPCKHLIKSHSCPTLAVVPCQRPDNYWSEFGTQSAHSDCADEEDSFVSDSSDQVQVCGRACFYQSRGLPLVRYAYNIPRMKD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
201	N-linked (GlcNAc...) asparagine	UniProt
296	N-linked (GlcNAc...) asparagine	UniProt
316	N-linked (GlcNAc...) asparagine	UniProt
384	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Regulation of FZD by ubiquitination	Xenopus tropicalis

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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International Collaboration

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