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MIRAGE

Hyaluronidase

Summary

UniProt ID: E1B8K4
Gene Symbol: HYAL4
Gene ID: 518161
Organism: Bos taurus (domestic cattle)

External Links

Re-Glyco: E1B8K4

Annotation

Keyword: Disulfide bond Glycosidase Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
carbohydrate metabolic process	IEA	GO_REF GO_REF
chondroitin sulfate proteoglycan catabolic process	IEA	GO_REF
hyaluronan catabolic process	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

hyaluronan metabolic process [inference]

hyaluronan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

hyaluronan metabolic process [inference]

hyaluronan catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

chondroitin sulfate proteoglycan catabolic process

Displaying **all 2** entries
GO Term	Evidence Code	Reference
cell surface	IEA	GO_REF
cytoplasmic vesicle	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying **all 2** entries
GO Term	Evidence Code	Reference
hyalurononglucosaminidase activity	IBA	GO_REF
hyalurononglucosaminidase activity	IEA	GO_REF GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hexosaminidase activity [inference]

hyalurononglucosaminidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKPLSEGQLRFYVVQAIHLISWLFILFILKSISSLKPARLPVYQRKPFIAAWNAPTDQCLIKYNIRLNLKMFQVIGSPLARARGQNVTIFYVNRLGYYPWYTPQGVPINGGLPQNISLQVHLEKADQDIRYYIPSEDFSGLAVIDWEYWRPQWARNWNTKDIYRQKSRKLISETQENASAADIEYLAKATFEESAKAFMKETIELGIKSRPKGLWGYYLYPDCHNYNVYGPNYTGSCPEEEVLRNNELSWLWNISAALYPSIGVRRSLGDSENVLRFSQFRVHESMRISIMTSRDHALPVFVYTRLGYRDQPLLFLSKQDLISTIGESAALGAAGIVIWGDMNLTSSKGNCTKVKQFVSSDLGSYIVNVTRAAEVCSLHVCRNNGRCIRKVWKMPDYLHLNPASYHIEASEDGEFTVKGRASDTDLAVLAERFSCHCYQGYQGADCREMKTADGCSGPSSFSGSLLTLCLLVSTGYQSRQW

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
368	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
CS/DS degradation	Bos taurus
Hyaluronan degradation	Bos taurus

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026