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Complement component C6

Summary

UniProt ID: E9Q6D8
Gene Symbol: C6
Gene ID: 12274
Organism: Mus musculus (house mouse)

External Links

Re-Glyco: E9Q6D8

Annotation

Keyword: Alternative splicing Calcium Disulfide bond EGF-like domain Glycoprotein Membrane attack complex Metal-binding Reference proteome Repeat Secreted Signal Sushi Target cell membrane Transmembrane beta strand

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
in utero embryonic development	IGI	PMID
positive regulation of activation of membrane attack complex	IMP	PMID
complement activation	ISO	GO_REF
complement activation	IBA	GO_REF
complement activation, classical pathway

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, GZMK pathway

cellular process [inference]

cell killing [inference]

killing of cells of another organism

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, GZMK pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

complement activation, GZMK pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation

positive regulation of activation of membrane attack complex

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of humoral immune response [inference]

positive regulation of complement activation

positive regulation of activation of membrane attack complex

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
membrane attack complex	ISO	GO_REF
membrane attack complex	IBA	GO_REF
membrane attack complex	IEA	GO_REF
obsolete extracellular space
plasma membrane	NAS	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

transmembrane transporter complex

transporter complex [inference]

transmembrane transporter complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

other organism part [inference]

other organism cell membrane

Displaying 1 entry
GO Term	Evidence Code	Reference
metal ion binding

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MTRHLTLCFILLVMLIDKSEACFCDHYPWTHWSSCSKSCNSGTQSRQRQVVVNDYYWKNLCDKLCIKQETRECNLQTCPINCVLGDYGTWSDCDPCTEKQVKVKSVLRPSQFGGQPCTEPLVTFQPCVPSKLCKIEETNCKNKFLCDSGRCIPSKLECNGENDCGDNSDERNCGRTKPVCTRIYTPIPSVQLMGTGFHFLAGEPRGEVLDNSFTGGICKLVKTSRASNPYRVSANLENVNFEVQTIEDDLKTEFYKNLISFEKNKNEDSLSVDERTKFFPIPIFHFSEKNEHSHYSSAFNKVIKASHKKDSSFIRIHKLIKVLNFTMKATDLQLSDVFLKALVHLPLEYNSAVYSRIFDDFGTHYFTSGSLGGKYDLIYQFSRQELQNSGLTEEEAQNCVQYETKKLKFLYMEIHKEDTCTKNKLSEKYGGSFLQGSEKSISLVQGGRSQQAAALAWEKGTSGPEENVYSEWLESVKENPAVVDYKLAPITDLVRNIPCAVTKRNNLRRALQEYAAKFDPCQCAPCPNNGRPRLSGTECLCVCQSGTYGENCERRSPGYKSDAVDGNWGCWSSWSACNAAYRRSRTRECNNPAPQRGGQSCGGKDQQEEDCTVSIMENVGQPCINDDEEMKEVDLAEPEAESGCSQPPLPENAFTWNEKKLYSVGEEVEISCLTGFTAVGFQYLRCLPDRTWSQGDVECQRTSCLKPVVQDVLTISPFQRVYQIGESIELTCPRGFVVAGPSRYTCKEDSWTPPISNSLTCEQAILTKSKDLCPPGQKQSGSKCICMSPEEDCSAYSEDLCIFDGGSSQYFTSSACKFLAGKCLNNTQSHFVHSGSCQEGLQLEWGLERLKLAVNSTKRVSCGYNTCYDWENCSAHTSNCVCLLPPQCSKDENQLYCVKIGSSMREKTVNICTLGAVRCANIKVEILNPGRCPD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
324	N-linked (GlcNAc...) asparagine	UniProt
825	N-linked (GlcNAc...) asparagine	UniProt
855	N-linked (GlcNAc...) asparagine	UniProt
872	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Regulation of Complement cascade	Mus musculus
Terminal pathway of complement	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements