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Integrin alpha-3

Summary

UniProt ID

F1MMS9

Gene Symbol

ITGA3

Gene ID

508490

Organism

Bos taurus (domestic cattle)

External Links

PubChem: F1MMS9
Re-Glyco: F1MMS9

Annotation

Keyword: Calcium Cell adhesion Cell junction Cell membrane Cell projection Cleavage on pair of basic residues Disulfide bond Glycoprotein Integrin Metal-binding Palmitate Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
system process	IEA	GO_REF
integrin-mediated signaling pathway	IBA	GO_REF
regulation of signal transduction	IEA	GO_REF
cell differentiation	IEA	GO_REF
system development	IEA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cellular developmental process [inference]

cell differentiation

cell motility [inference]

cell migration [inference]

leukocyte migration

multicellular organismal process [inference]

system process

developmental process [inference]

anatomical structure development [inference]

system development

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction

regulation of localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of response to stimulus [inference]

regulation of signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction

positive regulation of cellular process [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
integrin complex	IBA	GO_REF
integrin complex	IEA	GO_REF
cell surface	IBA	GO_REF
cell surface	IEA	GO_REF
filopodium membrane	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane region [inference]

cell projection membrane [inference]

filopodium membrane

Displaying **all 3** entries
GO Term	Evidence Code	Reference
signaling receptor activity	IBA	GO_REF
metal ion binding
protein heterodimerization activity	ISS	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGPGPSRAAGVLRPLLGMLALMVAASNRAASAFNLDTRFLVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAGAPRDLAVPDGYTNRTGAVYLCPLTAHKNDCERMDIKEKSNPNHIIEDMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCYVRGNDLELDARDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKDWDLSEYSYKDPEDQGNLYIGYTMQVGSAILHPTNITIVTGAPRHQHVGAVFLLSQEAGGDLRRRQVLEGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAIYIFMNQAGTSFPDHPSLLLHGPSRSAFGFSVASIGDVNQDGFQDIAVGAPFEGLGKVYIYHGSSRGLLRQPQQVIHGEQLGLPGLATFGYSLSGQMDVDENFYPDLLVGSLSDRIVLLRARPVINILHKTLVAKPSILDPAFCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLHFARSQSAVFHGFFSMPEMRCQTLELLLMDNVRDKLRPITISMNYSLPLRLPDRPQLGLGSLDAYPVLNQAQALENHTEVQFQKECGQDNRCDSNLQMRAAFVSELGQRLSRLQYRRDLRKLLLSINVTNTPSRKRAGEDAHEALLTLEVPPTLLLSSVRPPGACQANETIVCELGNPFKRNQRMELLIAFEVIGVTLHTRELQAQLQLSTSSHQDDLRPMTLPLLVDYTLQASLSMVNHRLQSFFGGTVMGESGMKTVEDVGSPLKYEFQVGPMGEGLAALGTLVLGLEWPYEVSNGKWLLYPTEITVHGNGSWHCQPPGDLINPLNLTLSVPGDGPPSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSEIQLSCGSDHTHCVWLECPIPDAPVITNVTIQARVWNSTFIEDYRDFDRVRVASWATLFLRTGVPTINMENKTVRFSVDIDSDLVEELPAEIELWLVLVAVSAGLLLLGLIILLLWKCGFFKRARTRALYEAKRQKAEMKSQPSETERLTEDY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 13 in total

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Position	Description	Source
86	N-linked (GlcNAc...) asparagine	UniProt
264	N-linked (GlcNAc...) asparagine	UniProt
499	N-linked (GlcNAc...) asparagine	UniProt
510	N-linked (GlcNAc...) asparagine	UniProt
572	N-linked (GlcNAc...) asparagine	UniProt
604	N-linked (GlcNAc...) asparagine	UniProt
655	N-linked (GlcNAc...) asparagine	UniProt
696	N-linked (GlcNAc...) asparagine	UniProt
840	N-linked (GlcNAc...) asparagine	UniProt
856	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Basigin interactions	Bos taurus
Integrin cell surface interactions	Bos taurus
Laminin interactions	Bos taurus
MET activates PTK2 signaling	Bos taurus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Acknowledgements