GlyCosmos Portal

Angiotensin-converting enzyme

Summary

UniProt ID: F1RRW5
Gene Symbol: ACE
Gene ID
Organism: Sus scrofa (pig)

External Links

PubChem: F1RRW5
Re-Glyco: F1RRW5

Annotation

Keyword: Calmodulin-binding Carboxypeptidase Cell membrane Cytoplasm Disulfide bond Glycoprotein Metal-binding Metalloprotease Phosphoprotein Reference proteome Repeat Secreted Signal Transmembrane helix Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	Reference
kidney development	ISS	GO_REF
kidney development	IEA	GO_REF
angiotensin maturation	ISS	GO_REF
angiotensin maturation	IBA	GO_REF
angiotensin maturation	IEA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

myeloid leukocyte mediated immunity [inference]

neutrophil mediated immunity

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

amyloid-beta metabolic process

cell population proliferation [inference]

cell proliferation in bone marrow

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

heart process [inference]

heart contraction

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin [inference]

maintenance of blood vessel diameter homeostasis by renin-angiotensin

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

animal organ development [inference]

kidney development

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

arachidonate transport [inference]

arachidonic acid secretion

icosanoid transport [inference]

icosanoid secretion [inference]

arachidonic acid secretion

arachidonate transport [inference]

arachidonic acid secretion

secretion [inference]

icosanoid secretion [inference]

arachidonic acid secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of protein metabolic process [inference]

regulation of angiotensin metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of angiotensin metabolic process

regulation of cell population proliferation [inference]

regulation of stem cell proliferation [inference]

regulation of hematopoietic stem cell proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of gap junction assembly [inference]

negative regulation of gap junction assembly

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of cell junction assembly [inference]

negative regulation of cell junction assembly [inference]

negative regulation of gap junction assembly

regulation of gap junction assembly [inference]

negative regulation of gap junction assembly

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of blood pressure

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin [inference]

maintenance of blood vessel diameter homeostasis by renin-angiotensin

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure

regulation of hormone levels [inference]

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

regulation of synaptic plasticity

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

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GO Term	Evidence Code	Reference
obsolete extracellular space
lysosome	IEA	GO_REF
endosome	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
metallocarboxypeptidase activity	IEA	GO_REF
metalloendopeptidase activity	ISS	GO_REF
metalloendopeptidase activity	IEA	GO_REF
calmodulin binding
peptidase activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

bradykinin receptor binding

calmodulin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

chloride ion binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGAASGCRWPWPPLLPLLLMLLLPPPPLPVALALDSALQPGNFTADEAGAEDFAQSFNSSSEQVLFQSTAASWAHDTNITEENARRQEEAALISQEFSEVWGQKAKALYDPIWQNFTSRTLRRIIGVVRTLGSANLSPAKRQQYNSLLSNMTRIYSTAKVCFPNKTATCWSLDPELTNILATSRSYTLLLYAWEGWHNAAGIPLKPLYQDFTALSNEAYKQDGFSDTGAYWRSLYDSPTFTEDLERLYHQLEPLYLNLHAYVRRALHRQYGDRFINLRGPIPAHLLGNMWAQSWNNIYDMVVPFPGKPSLDVTSAMVQKGWNVTHMFRVAEEFFTSLGLLPMPPEFWAESMLEKPSDGREVVCHASAWDFYNRKDFRIKQCTQVTMDQLSTVHHEMGHVQYYLQYKDQHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDHVTSDWESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPLYNYDWWYLRTKYQGVCPPVVRNETHFDAGAKYHVPNVTPYIRYFVSFILQFQFHQALCKEAGHQGPLHQCDIYQSTRAGAKLRAVLQAGSSRPWQEVLKDMVGSGALDAQPLLDYFQPVTQWLEEQNQRSGDILGWPEYQWRPPMPDNYPEGIDLVSDEAEASKFVEEYDRRSQVVLNEYAEANWDYNTNITAEGSKRVLEKSTQMANHTVKYGIWARKFDVANIQNFTLKRMIKKIQDLERAALPFKELEEYNQILLDMETAYSVASVCHANSTCLQLEPDLTNLMATSRSYEELLWAWKGWRDKVGRAILPYFPKYVELTNKAARLNGYEDGGDAWRAAYEMPFLEQELEQLFQELQPLYLNLHAYVRRALHHHYGPEHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSASKMDASEAMINQGWTPQRMFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFFNGKDFRIKQCTTVNMEDLVVAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLRSINLLKSEDDGYEEDINFLMKMALDKVAFVPFSYLVDQWRWRVFDRSITKENYNQEWWSLRLKYQGLCPPVARSQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHKGPLHKCDIYQSKEAGRRLADAMKLGLSKPWPEAMQLITGQPNVSASAMMTYFKPLLDWLVTENGRHGEKLGWPQYNWTPNSARLEGSFAGTGRVNFLGLNLEEQQARVGQWVLLFLGVTLLVATMGLTQRLFSIRHQILRRTHRGPQFGSEVELRHS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	Source
42	N-linked (GlcNAc...) asparagine	UniProt
58	N-linked (GlcNAc...) asparagine	UniProt
78	N-linked (GlcNAc...) asparagine	UniProt
115	N-linked (GlcNAc...) asparagine	UniProt
135	N-linked (GlcNAc...) asparagine	UniProt
150	N-linked (GlcNAc...) asparagine	UniProt
164	N-linked (GlcNAc...) asparagine	UniProt
322	N-linked (GlcNAc...) asparagine	UniProt
512	N-linked (GlcNAc...) asparagine	UniProt
526	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Metabolism of Angiotensinogen to Angiotensins	Sus scrofa

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements