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Catechol O-methyltransferase A

Summary

UniProt ID

F4ZGF2

Gene Symbol

comta

Gene ID

561372

Organism

Danio rerio (zebrafish)

External Links

Re-Glyco: F4ZGF2

Annotation

Keyword: Alternative splicing Catecholamine metabolism Glycoprotein Magnesium Metal-binding Methyltransferase Neurotransmitter degradation Reference proteome S-adenosyl-L-methionine Secreted Signal

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	Reference
methylation
developmental process	IBA	GO_REF
dopamine metabolic process	IBA	GO_REF
catecholamine catabolic process	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

amine catabolic process [inference]

biogenic amine catabolic process [inference]

catecholamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

amine catabolic process [inference]

biogenic amine catabolic process [inference]

catecholamine catabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

methylation

developmental process

Displaying 1 entry
GO Term	Evidence Code	Reference
extracellular region	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

Displaying **all 4** entries
GO Term	Evidence Code	Reference
magnesium ion binding	IEA	GO_REF
catechol O-methyltransferase activity	IDA	PMID
catechol O-methyltransferase activity	IBA	GO_REF
catechol O-methyltransferase activity	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

O-methyltransferase activity [inference]

catechol O-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

catechol O-methyltransferase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLWVVLAVVVVLASVLVLLRQSSGLLALLWHDVVHQRLLNFFTGLSRPQRILKAVQKNATKGNPESVIAAIDHYCRHSEWAMNVGDEKGLILDSVVTEVNPSTALELGTYCGYSTVRIARLLSPGTKLITLEFNPDYAAIARQIIAYAGLQDKVILVEGPSGDLIPKMKQQHGIKSFDFVFLDHWKDRYVPDTKLLEECGLLRKGSVLLADNVICPGTPEYLKYVRNDPRYESRYFKSNLEYTKVEDGLEKSVFLG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
58	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Enzymatic degradation of Dopamine by monoamine oxidase	Danio rerio
Enzymatic degradation of dopamine by COMT	Danio rerio
Methylation	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements