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Prothrombin

Summary

UniProt ID

G3QVP5

Gene Symbol

F2

Gene ID

101149905

Organism

Gorilla gorilla gorilla (western lowland gorilla)

External Links

Re-Glyco: G3QVP5

Annotation

Keyword

Acute phase
Blood coagulation
Cleavage on pair of basic residues
Disulfide bond
Gamma-carboxyglutamic acid
Kringle
Reference proteome
Serine protease
Signal

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
extracellular space
collagen-containing extracellular matrix
endoplasmic reticulum lumen
external side of plasma membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **21 - 25** of 25 in total

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GO Term
neutrophil-mediated killing of gram-negative bacterium
positive regulation of protein localization to nucleus
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
ligand-gated ion channel signaling pathway
thrombin-activated receptor signaling pathway

Displaying **all 6** entries
GO Term
lipopolysaccharide binding
serine-type endopeptidase activity
calcium ion binding
heparin binding
thrombospondin receptor activity
receptor ligand activity

Annotation information from UniProt.

Sequence

MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECMEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPSEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDPDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
121	N-linked (GlcNAc...) (complex) asparagine	UniProt
143	N-linked (GlcNAc...) (complex) asparagine	UniProt
416	N-linked (GlcNAc...) (complex) asparagine	UniProt