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Receptor-type tyrosine-protein phosphatase

Summary

UniProt ID: H2KZM6
Gene Symbol: clr-1 F56D1.4
Gene ID: 3565419
Organism: Caenorhabditis elegans

External Links

GlycoProtDB: GPDB0000298
PubChem: H2KZM6
Re-Glyco: H2KZM6

Annotation

Keyword: Alternative splicing Cell membrane Disulfide bond Immunoglobulin domain Neurogenesis Protein phosphatase Reference proteome Signal Synapse Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
signal transduction	IBA	GO_REF
sensory perception of chemical stimulus	IMP	PMID
chemosensory behavior	IMP	PMID
neuron projection development	IBA	GO_REF
netrin-activated signaling pathway	IGI	PMID

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling

signal transduction

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus

behavior [inference]

chemosensory behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of fibroblast growth factor receptor signaling pathway [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

signaling [inference]

cell-cell signaling [inference]

synaptic signaling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of fibroblast growth factor receptor signaling pathway [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of fibroblast growth factor receptor signaling pathway [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of fibroblast growth factor receptor signaling pathway [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of fibroblast growth factor receptor signaling pathway

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

Displaying **all 3** entries
GO Term	Evidence Code	Reference
plasma membrane	IDA	PMID
plasma membrane	IEA	GO_REF
postsynapse	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

postsynapse

Displaying **all 5** entries
GO Term	Evidence Code	Reference
protein tyrosine phosphatase activity	EXP	PMID
protein tyrosine phosphatase activity	IBA	GO_REF
protein tyrosine phosphatase activity	IEA	GO_REF GO_REF GO_REF
transmembrane receptor protein tyrosine phosphatase activity	IDA	PMID
transmembrane receptor protein tyrosine phosphatase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRINRWIWWATVILLYLRTGLAADFFRSSEENDRKSSDDLDNFNSTKIEPDKPKTAKELGVKSCESNQDCVHDGVCHRGNDGHGICMCPRSCPAITPKQCGYNYRTPSTCLLMDADYRSKYDVKEPTCYSRKCVCPPQFDDVHVTANQKPLRLNSTLLPTKCDKRDLAVVARAHPSTSVSKGIDVTLFCCINVDPEGFIDVASVFFIQNGTIMREATSHPFAPRNGLARRVHEKYSCWELEIKNAQTSDSGSYMCRVTASASDLDVTDTMQFEVKAPRQIKNLTVNPSERDAIVTWESEGGEDMAIDLRLVRRTDTRGQVVFSKDNLTSPVSIKDLRAATPYTLFVSGNNGQVPFEFTEHFTTKQKRPFPPKEEDVRVLNSGSALSCEVEWKSPAEPNGRITKYFVSVRGAMRKSDGSLTPDDLPAAVEVDKRCANWDGDENTSKHNGINPIDFANEFYSCKFGPLKPNRNYTVTVWAENSAGRSLPAVFHKNCVTNYAQPDMVETPQPLLSNNHSTFSLTFPQPPDDINGPISCYYIAIVPLPANVSLDILPKSEEIVMHSFSKVFTNNLLPSSAEEKRFFAYIAESYVQLPEETTIGDGVRVSDLKACNVQYLSRYSSEDLALRRGLKYTGFLIVRVDKEEELNRKDVRNGADPNIFRNLIDKSVSPTSRTRTASPMSRHLRQLHLSGPAYGYSAYFKPILLDTESSSSGFGIFMKIILPFLLFLAFATGVTMFFVNRKGHMLSTWCPLFTKMTSKDVVERTLLKQTFGAIPVDDLPTEYVVRHRDTDFLFAQEYESLPHFQLDTVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGPDVIPNGNGVEYANVPIVKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMYGDTDEDVRDFEDHYQRLCASNRDRAVSFNQQSSTNGSISPRVAIVSSRESMTTSNGETGLEEEFKKLERNLTTPLSSNFAAKDENLLKNRYEAAVPFDKYRVILPPTIGHADSSYINASHIKGYFFDYIAAQDPVSEGTAFDFWRMIADQNVTTVVMLSDETDWSDVEKYWPIDGSGTECHFGSERNSVNVTCVSEEHHQDFIIRNLSYSMKDNESMPANQEVVQYSYTGWPSDSIVPKSANSLMNLIEMVLQRQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQSHRPMMFTRFEQYSFCYRALADYISKTYR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
154				GlycoProtDB
326				GlycoProtDB

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements