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Lactotransferrin

Summary

UniProt ID: K9IMD0
Gene Symbol: LTF
Gene ID
Organism: Desmodus rotundus (common vampire bat)

External Links

PubChem: K9IMD0
The Human Metabolome Database: HMDBP13735
Re-Glyco: K9IMD0

Annotation

Keyword: Antibiotic Blood coagulation cascade inhibiting toxin Direct protein sequencing Disulfide bond Glycoprotein Immunity Iron transport Metal-binding Osteogenesis Repeat Secreted Serine protease Signal

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
ossification
proteolysis
iron ion transport	IEA	GO_REF
antibacterial humoral response	IEA	GO_REF
negative regulation of blood coagulation	IDA	PMID PMID PMID

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

multicellular organismal process [inference]

ossification

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

antibacterial humoral response

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of wound healing [inference]

negative regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of coagulation [inference]

negative regulation of blood coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation

Displaying **all 4** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
early endosome	IEA	GO_REF
plasma membrane	IEA	GO_REF
recycling endosome	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying **all 3** entries
GO Term	Evidence Code	Reference
serine-type peptidase activity
metal ion binding
toxin activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

serine-type peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

serine-type peptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

toxin activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKLLFLALLSLLALGPSLAARRRGVRWCTISKPEAAKCSKLQQNLKRVRGPSLSCISRKSYLECIQAIAAKRADAMSLDAGLVYEAGQDPYRLRPVAAEVYGTEGAPRTHYYAVALVKKDSNLQLNQLQGVRSCHTGLNRSAGWKIPVGTLRPYLGWAGPPAPLQEAVANFFSASCVPCADGNQYPNLCRLCAGTGADKCACSSKEPYFGYSGAFKCLKDGAGDVAFVKDSTVFENLPNKAERDQYELLCPDNTRKPVDEFEQCHLARVPSHAVVARSVGGKEDSIWRLLSKAQEKFGKGTSGSFQLFSSPPGQKDLLFKDGAQGFLRIPSRVDAELYLGPSYLTVIKNLKESAAEVEARGARVVWCAVGPEELRKCQQWSGQSNGTVTCTTAADTEDCIALVLKGEADAMSLDGGVIYIAGKCGLAPVLAESQRSEGGSNLDCVNRPLEGDRAVAVVRKSSAGLTWNSRRGTKSCHTAVGRTAGWNIPMGLLFNQTRSCNFDEFFSQSCAPGADPNSNLCALCVGNEQGQDKCAPNSNERYFSYAGSFRCLVENAGDVAFVKASTVLENPDGRGTEAWAKDLKLEDFELLCLDGTRKPVSEFETCHLARAPSHGVVSRKDRVQYLEQVLLDQQGKFGRNGPLCPGKFCLFQSETKNLLFNDNTECLAKLQGKTTYEKYLGPEYVTAVANLRQCSTSPLLEACTFLRN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
139	N-linked (GlcNAc...) asparagine	UniProt
385	N-linked (GlcNAc...) asparagine	UniProt
495	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements