GlyCosmos Portal

Submissions

Left-right determination factor 2

Summary

UniProt ID

O00292

Gene Symbol

EBAF
LEFTA
LEFTY2
LEFTYA
PSEC0024
TGFB4

Gene ID

[7044]

Organism

Homo sapiens (human)

External Links

Re-Glyco: O00292

Annotation

Keyword: Alternative splicing Cytokine Developmental protein Disease variant Disulfide bond Glycoprotein Growth factor Heterotaxy Proteomics identification Reference proteome Secreted Signal

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	Reference
anterior/posterior axis specification	IBA	GO_REF
BMP signaling pathway	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

multicellular organismal process [inference]

pattern specification process [inference]

axis specification [inference]

anterior/posterior axis specification

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome
extracellular region	IEA	GO_REF GO_REF
obsolete extracellular space
extracellular matrix	HDA	PMID
platelet alpha granule lumen	TAS	Reactome

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

Displaying **all 3** entries
GO Term	Evidence Code	Reference
cytokine activity	IBA	GO_REF
transforming growth factor beta receptor binding	IEA	GO_REF
growth factor activity	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

transforming growth factor beta receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWPLWLCWALWVLPLAGPGAALTEEQLLGSLLRQLQLSEVPVLDRADMEKLVIPAHVRAQYVVLLRRSHGDRSRGKRFSQSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
158	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Platelet degranulation	Homo sapiens
Regulation of signaling by NODAL	Homo sapiens
Signaling by NODAL	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1682	congenital heart disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements