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Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

Summary

UniProt ID: O00469
Gene Symbol: PLOD2
Gene ID: 5352
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011162

GlyConnect

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

GlyGen

O00469

PubChem

O00469

The Human Metabolome Database

HMDBP00461

The O-GlcNAc Database

O00469

RaftProt

O00469

O-GlcNAcAtlas

O00469

Re-Glyco

O00469

Annotation

Keyword: Alternative splicing Cytoplasm Dioxygenase Disease variant Endoplasmic reticulum Glycoprotein Iron Membrane Metal-binding Osteogenesis imperfecta Phosphoprotein Proteomics identification Reference proteome Signal Vitamin C

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
response to hypoxia	IEP	PMID
collagen fibril organization	IBA	GO_REF
collagen biosynthetic process	ISS	PMID
collagen biosynthetic process	IDA	PMID
collagen biosynthetic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

collagen biosynthetic process

collagen metabolic process [inference]

collagen biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

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GO Term	Evidence Code	Reference
obsolete extracellular space
cytoplasm	IMP	PMID PMID
cytoplasm	IEA	GO_REF
endoplasmic reticulum	TAS	PMID
endoplasmic reticulum	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

rough endoplasmic reticulum membrane

bounding membrane of organelle [inference]

rough endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	Reference
iron ion binding	IEA	GO_REF
procollagen-lysine 5-dioxygenase activity	ISS	PMID
procollagen-lysine 5-dioxygenase activity	IDA	PMID PMID
procollagen-lysine 5-dioxygenase activity	IBA	GO_REF
procollagen-lysine 5-dioxygenase activity	IEA	GO_REF GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

catalytic activity, acting on a protein [inference]

procollagen-lysine 5-dioxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
33		23301498 26853435 33214551 33465208 34019948 34725712 35008409 38665916 39531497 40596516 41018975	G49108TO	GlyGen The O-GlcNAc Database
63	N-linked (GlcNAc...) asparagine	23345538 29741879 37074911	G37412TK G63381RX G83460ZZ G60033FS G80920RR G34730YF G67324HN G37399XV G62765YT G64527OM G31852PQ G39188ZX G41247ZX G02815KT	GlycoProtDB UniProt GlyGen GlyConnect
209	N-linked (GlcNAc...) asparagine	19159218 23090970 24190977 29741879 34089345 37074911	G39471UU G78787DI G61256FT G63381RX G72667IM G76295SF G83460ZZ G35253PZ G70101JE G80920RR G62765YT G64527OM G31852PQ	UniProt GlyGen GlyConnect
297	N-linked (GlcNAc...) asparagine			UniProt GlyGen
365	N-linked (GlcNAc...) asparagine	37074911	G80920RR G62765YT G31852PQ G41247ZX	UniProt GlyGen
522	N-linked (GlcNAc...) asparagine	19159218 34089345 37074911	G85554PZ G96430BV G15664MX G72747WU G46503DX G80920RR G90659AW G83633GK G62765YT G05049YU G31852PQ G23719VF G41247ZX G02815KT	UniProt GlyGen
696	N-linked (GlcNAc...) asparagine	29741879 34089345 37074911	G80479JV G20706XG G00912UN G83460ZZ G72747WU G59626AS G80920RR G77547TA G37399XV G62765YT G64527OM G05724UK G31852PQ G90575OW G39188ZX G41247ZX G50282JC G36379GD G02815KT G06110VR G92050GC G92275SC G28681TP	GlycoProtDB UniProt GlyGen GlyConnect
698			G49108TO	GlyGen
725	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen
727		23301498 26853435 33214551 33465208 34019948 34725712 35008409 38665916 39531497 40596516 41018975	G49108TO	The O-GlcNAc Database