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MIRAGE
Presenilin homolog
Summary
- UniProt ID
- O02194
- Gene Symbol
- 0480/15 0493/14 493/14 CG18803 CG5868 DPS DPsn DmPS Dmel\CG18803 Dmel_CG18803 Dps DrosPS PS PS1 PSN Psn dPsn gamma-secretase l(3)77CDb l(3)S048015a l(3)S049314 l(3)S049314a pres psn
- Gene ID
- 40260
- Organism
- Drosophila melanogaster (fruit fly)
Annotation
- Keyword
- Alternative splicing Endoplasmic reticulum Glycoprotein Golgi apparatus Notch signaling pathway Protease Reference proteome Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| proteolysis | ||
| membrane protein ectodomain proteolysis | ||
| membrane protein ectodomain proteolysis | ||
| apoptotic process | ||
| Notch signaling pathway |
| GO Term | Evidence Code | Reference |
|---|---|---|
| Golgi membrane | ||
| endoplasmic reticulum membrane | ||
| gamma-secretase complex | ||
| gamma-secretase complex | ||
| gamma-secretase complex |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| endopeptidase activity | ||
| endopeptidase activity | ||
| endopeptidase activity | ||
| aspartic endopeptidase activity, intramembrane cleaving | ||
| aspartic endopeptidase activity, intramembrane cleaving |
GO Hierarchy
Sequence
MAAVNLQASCSSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMEDLSAKQVFI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 129 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| EPH-ephrin mediated repulsion of cells | Drosophila melanogaster |
| Neutrophil degranulation | Drosophila melanogaster |
| Nuclear signaling by ERBB4 | Drosophila melanogaster |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10652 | Alzheimer's disease | |
| DOID:12930 | dilated cardiomyopathy | |
| DOID:0110042 | Alzheimer's disease 3 | |
| DOID:0060894 | early-onset Parkinson's disease |
