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Delta(14)-sterol reductase LBR

Summary

UniProt ID: O08984
Gene Symbol: Lbr
Gene ID
Organism: Rattus norvegicus (Norway rat)

External Links

GlyGen: O08984
PubChem: O08984
O-GlcNAcAtlas: O08984
Re-Glyco: O08984

Annotation

Keyword: Acetylation Cholesterol biosynthesis Cytoplasm DNA-binding Endoplasmic reticulum Glycoprotein Nucleus Oxidoreductase Phosphoprotein Receptor Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
cholesterol biosynthetic process	ISS	GO_REF
cholesterol biosynthetic process	ISO	GO_REF
cholesterol biosynthetic process	IBA	GO_REF
cholesterol biosynthetic process	IEA	GO_REF
neutrophil differentiation	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

zymosterol metabolic process [inference]

zymosterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

zymosterol metabolic process [inference]

zymosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

granulocyte differentiation [inference]

neutrophil differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

granulocyte differentiation [inference]

neutrophil differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

sex-chromosome dosage compensation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

heterochromatin organization [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

cellular component assembly [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

granulocyte differentiation [inference]

neutrophil differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

granulocyte differentiation [inference]

neutrophil differentiation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

epigenetic regulation of gene expression [inference]

sex-chromosome dosage compensation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

epigenetic regulation of gene expression [inference]

sex-chromosome dosage compensation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome [inference]

random inactivation of X chromosome

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	Reference
fibrillar center
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF
nucleus	IEA	GO_REF
nuclear envelope	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear pore

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle inner membrane [inference]

nuclear inner membrane

nuclear membrane

nuclear inner membrane

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
DNA binding
nuclear localization sequence binding
Delta14-sterol reductase activity	ISS	GO_REF
Delta14-sterol reductase activity	ISO	GO_REF
Delta14-sterol reductase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

Delta14-sterol reductase activity

binding [inference]

nucleic acid binding [inference]

DNA binding

protein binding [inference]

protein domain specific binding [inference]

chromo shadow domain binding

protein-folding chaperone binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

NADPH binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADPH binding

peptide binding [inference]

signal sequence binding [inference]

nuclear localization sequence binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADPH binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

chromatin-protein adaptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPGRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKESDIKPLKSFKQRKSGSTSSSPSRRRSSRSRSRSRSRSPGRAPKGSRRSVSASYQADAKEKEMRREILQVKLTPLVLKPFANSVSVYNGEPEHMEKSATPPKNKQERVILSTEDSYIATQYSLRPRREEVKPKHRVRGTNLVTRGPVPLGTFQVTTPQRRDLEFGGVPGALLIMLGLPACVFLLLLQCAQKDPGLLQFPPPLPALRELWEARVCGVYLLWFFLQALFSLLPVGKVVEGTPLVDGRRLKYRLNGLYAFILTSAAVGTAVFWDIELYYLYTHFLQFALAAIVFSVVLSVYLYARSLKVPRDELSPASSGNAVYDFFIGRELNPRIGAFDLKFFCELRPGLIGWVVINLVMLLAEMKVQERSAPSLAMTLVNSFQLLYVVDALWFEEALLTTMDIIHDGFGFMLAFGDLVWVPFTYSLQAFYLVNHPQDLSWPLTSVIIALKLCGYVIFRCANSQKNAFRKNPTDPKLAHLKTIPTSTWKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYVIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
96	O-linked (GlcNAc) serine	12438562	G49108TO	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
CDC42 GTPase cycle	Rattus norvegicus
Cholesterol biosynthesis via desmosterol (Bloch pathway)	Rattus norvegicus
Initiation of Nuclear Envelope (NE) Reformation	Rattus norvegicus
RAC1 GTPase cycle	Rattus norvegicus
RAC2 GTPase cycle	Rattus norvegicus
RAC3 GTPase cycle	Rattus norvegicus
RHOA GTPase cycle	Rattus norvegicus
RHOC GTPase cycle	Rattus norvegicus
RHOG GTPase cycle	Rattus norvegicus
Regulation of MECP2 expression and activity	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

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International Collaboration

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