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Guidelines
MIRAGE
Disintegrin and metalloproteinase domain-containing protein 10
Summary
- UniProt ID
- O14672
- Gene Symbol
-
- ADAM10
- KUZ
- MADM
- Gene ID
- 102
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Alzheimer disease
- Amyloidosis
- Cell junction
- Cell membrane
- Cell projection
- Cleavage on pair of basic residues
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Metal-binding
- Metalloprotease
- Neurodegeneration
- Notch signaling pathway
- Phosphoprotein
- Reference proteome
- SH3-binding
- Signal
- Transmembrane helix
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi apparatus |
| Golgi-associated vesicle |
| adherens junction |
| cell surface |
| clathrin-coated vesicle |
| perinuclear endoplasmic reticulum |
| focal adhesion |
| postsynaptic density |
| extracellular exosome |
| pore complex |
Sequence
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 31 |
|
|||
| 36 |
|
|||
| 37 |
|
|
||
| 124 |
|
|||
| 130 |
|
|||
| 194 |
|
|||
| 248 |
|
|||
| 267 | N-linked (GlcNAc...) asparagine | |||
| 269 |
|
|||
| 278 | N-linked (GlcNAc...) asparagine |
G57321FI
G43417UB
G49108TO
G00912UN
G80920RR
G62765YT
G02815KT
G57776ZS
G20706XG
G15664MX
G83460ZZ
G70223PD
G46503DX
G25079LO
G70101JE
G90659AW
G64527OM
G31852PQ
G41247ZX
G92050GC
G28681TP
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | Homo sapiens |
| Amyloid fiber formation | Homo sapiens |
| Collagen degradation | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | Homo sapiens |
| Degradation of the extracellular matrix | Homo sapiens |
| EPH-ephrin mediated repulsion of cells | Homo sapiens |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060258 | reticulate acropigmentation of Kitamura | |
| DOID:0110050 | Alzheimer's disease 18 |
