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MIRAGE
3-phosphoinositide-dependent protein kinase 1
Summary
- UniProt ID
- O15530
- Gene Symbol
-
- PDK1
- PDPK1
- Gene ID
- [5170]
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure ATP-binding Acetylation Activator Alternative splicing Cell junction Cell membrane Cytoplasm Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transcription regulation Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| type B pancreatic cell development | ||
| protein phosphorylation | ||
| hyperosmotic response |
|
|
| epidermal growth factor receptor signaling pathway | ||
| insulin receptor signaling pathway |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of transmembrane transport [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| 3-phosphoinositide-dependent protein kinase activity |
Sequence
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 5 |
|
|||
| 6 |
|
|||
| 22 |
|
|||
| 45 |
|
|||
| 92 |
|
|||
| 105 |
|
|||
| 222 |
|
|||
| 354 |
|
|||
| 366 |
|
|||
| 381 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of PKB | Homo sapiens |
| CD28 dependent PI3K/Akt signaling | Homo sapiens |
| CLEC7A (Dectin-1) signaling | Homo sapiens |
| Constitutive Signaling by AKT1 E17K in Cancer | Homo sapiens |
| Downstream TCR signaling | Homo sapiens |
| Estrogen-stimulated signaling through PRKCZ | Homo sapiens |
| FCERI mediated NF-kB activation | Homo sapiens |
| G beta:gamma signalling through PI3Kgamma | Homo sapiens |
| GPVI-mediated activation cascade | Homo sapiens |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10283 | prostate cancer |
